Senator Edward M. Kennedy, known as the "liberal lion of the Senate," died late Tuesday at his home in Hyannis Port, Massachusetts, reports the Los Angeles Times. His remarkable leadership efforts to assist those living with HIV/AIDS resulted in the Ryan White CARE Act, which provides federally funded services to improve the care of those living with HIV.

Kennedy, a Democrat known for his progressive political views, was admired by senators on both sides of the aisle, and he created groundbreaking legislative measures on Capitol Hill.

As a firm believer in the government’s ability to solve people’s problems, he also played a significant role in the 1965 Voting Rights Act and sponsored the Civil Rights Act of 1991. He also influenced laws that deregulated airlines and that helped workers keep their medical insurance if they lost or changed jobs.

His family and colleagues expressed their grief about his death.

"We’ve lost the irreplaceable center of our family and joyous light in our lives, but the inspiration of his faith, optimism and perseverance will live on in our hearts forever," his family said via a statement.

"Senator Kennedy had a grand vision for America and an unparalleled ability to effect change," said Nancy Pelosi, speaker of the House.

His brothers, President John F. Kennedy and Senator Robert F. Kennedy, were both assassinated in the 1960s.

Edward Kennedy died of cancer from a malignant brain tumor.