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This article is poorly written and provides no meaningful data. In the 8th paragraph the author states that the individuals taking the older seisure meds were 4.5X more likely to have treatment failure and then in went on to say,"The difference between people on the older anti-seizure drugs and those taking no anti-seizure medication was less meaningful, however." The author tried to identify patterns but did not clearly establish a causal relationship between the 3 groups of test subjects.
I have HIV induced eplepsy. My experience is not failure to maintain viral suppression, but failure of the anti seizure meds Dilantin then Zonigram was added and that has causes exacerbation of neuropathy. Hideous AM Med Hang over, that doubles after my AM antiviral pass as liver dumps toxins to work on HIV meds. Anti Epileptics aren't covered on ADAP formularies end up o o pocket, new anti seiz drugs are expensive. Lack of access to epileptologists makes things harder all around. not covered
David Evans, AIDSmeds
While there was a difference in the risk of treatment failure between those on older versus newer anti-seizure meds, there was less difference between those NOT taking seizure meds and those taking older-seizure meds. The authors don't provide an explanation, but argue that there may have been more significant differences in terms of baseline viral load and and adherence between those on and off seizure meds compared with the two groups that were both taking seizure meds.
June 23, 2011 • New York, NY