April #100 : Warning Signs

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Table of Contents

Getting Out Alive

Last Call

He Said, He Said

Outside In

Myth vs. Reality in the Pen

The Hook-Up

Africa’s Mayor

3 x 5 Report Card

Tribute: Wilfredo Valencia Palacios Roman

Earthwatch: Prison Focus

Website of the month: AIDSVote.org

Medicare Malaise

See You in the Lobby

Show & Tell: Oscar Time



Cirque du So Lame

Can HIV Care Click in the Clink?

A Bitter Pill

Comfort Zone: SpiceBoy

The Sweetest Taboo

Diamond in the Roughage

Head Games

Looking for Liver Helpers

Quick Study: Painkiller


Cheek to Chic

Warning Signs

Quick Study: Sexual Satisfaction

Publisher’s Letter


Live To Tell: With Conviction

Most Popular Lessons

The HIV Life Cycle


Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

email print

April 2004

Warning Signs

Viramune: Boehringer Ingelheim (BI), maker of the non-nuke Viramune (nevirapine), is issui

Viramune: Boehringer Ingelheim (BI), maker of the non-nuke Viramune (nevirapine), is issuing a “Dear Doctor” letter saying the med may spell trouble in first-line combos for women with CD4 counts over 250 and men over 400.

Viramune boosts those women’s risk of liver disease and rash almost tenfold (from 1.1 percent to 9.7 percent), the men’s almost seven times (from 0.7 percent to 3.6 percent). HIV expert Antonio Urbina, MD, says high CD4 counts invite danger because stronger immune systems are more likely to attack Viramune as an invader. But he says, “The warning applies only to those about to start Viramune. For those on it and doing well, there’s no need to stop or switch meds.”

“Viramune already had a black-box warning [for] fatal liver toxicity, including hepatitis and necrosis, in patients with high CD4 counts,” says an FDA spokesperson, adding that you should watch for the problems for 18 weeks, though the greatest risk falls in the first six weeks of treatment.

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