May #101 : Future Hits - by Ivan Oransky MD

POZ - Health, Life and HIV
Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:

Back to home » Archives » POZ Magazine issues




Table of Contents

The POZ Decade-Bare Witness

The POZ Decade

The POZ Decade-1994

The POZ Decade-1995

The POZ Decade-1996

Let’s Talk About Sex

The POZ Decade-1997

The POZ Decade-1998

The POZ Decade-1999

The POZ Decade-2000

The POZ Decade-2001

Star Wars

The POZ Decade-2002

The POZ Decade-2003

Tributes

Catching Up

Come Together Right Now

10 Unsung Heroes

Then & Now

Death Wish

In Sickness & in Health

In My Life

Angels & Devils

Postscripts From the Edge

Where It’s At

Below the Radar

The Right Moves

Vital Signs

Checkup Check-In

Wish You Were Here?

Future Hits

Future Blocks

Top 10 Side Effects

Nurse Knew It All

10 More Pills

Fabulously Positive

The 10 Wackiest AIDS “Cures"

Founder's Letter

Mailbox

The Gift of Life



Most Popular Lessons

The HIV Life Cycle

Shingles

Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV


email print

May 2004

Future Hits

by Ivan Oransky MD

Researchers are targeting 10 steps in HIV’s M.O. to give us new treatments


1. Slimy Surface
HIV needs to be covered in fat to make its grand entrance into cells. Researchers are trying to keep the virus out by disrupting this surface fat with creams.

2. Entry
To enter your cells, HIV’s protein spikes attach to a molecule on the cell’s surface, bind to another and then fuse with your cell membrane. Entry Inhibitors to block each step are near (one, Fuzeon, is here).

3. Capsid
Inside your cells, HIV has to shed a protein coat (capsid) encasing its genetic material. In February, scientists discovered a protein (TRIM5-alpha) that blocks the shedding—in monkeys.

4. Reverse Transcriptase (RT)
Enzyme RT makes HIV’s genetic material—coded as RNA—more like your cell’s genetic material, coded as DNA. Blocking that step is central to stopping HIV’s life cycle—that’s why all those nukes and non-nukes target RT. Simpler, more effective RT-inhibiting meds are on the way.

5. Integrase
To reproduce, HIV has to get its genes into your cell’s genes. The enzyme integrase does the trick. A few integrase inhibitors have hit HIV in the lab, but none has yet been shown to work in humans.

6. Protease
Once entwined with your cell’s genes, the virus can trick the cell into making the proteins to build new HIV. But those need some postproduction work—enter the enzyme protease. We’ve got eight protease inhibitors (PIs), with more in store.

7. Virus Formation
Next, HIV’s proteins have to get together and form a virus. One treatment in the works may be able to muck up this step.

8. Viral Infectivity Factor (Vif)
Vif, a protein HIV needs late in the process of viral formation, disrupts an enzyme in your own cells (APOBEC3G) that would normally block infection. Researchers’ challenge: Stop Vif from getting to APOCEC3G.

9. Immune System’s Cells
The body’s own cells are able to fight bacteria and viruses—including HIV. Stimulating these cells’ growth hasn’t worked very well so far, because it can give HIV more cells to infect. But with kinks removed, this could bolster current treatments.

10. Complacency
One stage of the HIV life cycle may be in the brain: thinking HIV isn’t a personal and global danger. We need to fight the idea that HIV’s peril is a thing of the past.




[Go to top]

Join POZ Facebook Twitter Google+ MySpace YouTube Tumblr Flickr
Quick Links
Current Issue

HIV Testing
Safer Sex
Find a Date
Newly Diagnosed
HIV 101
Disclosing Your Status
Starting Treatment
Help Paying for Meds
Search for the Cure
POZ Stories
POZ Opinion
POZ Exclusives
Read the Blogs
Visit the Forums
Job Listings
Events Calendar


    dversescott
    Baltimore
    Maryland


    july8th69
    brooklyn
    New York


    Sexynyrican
    Brooklyn
    New York


    jacob2608
    Panama City Beach
    Florida
Click here to join POZ Personals!
Ask POZ Pharmacist

Talk to Us
Poll
Do you work with your doc to design your own treatment regimen?
Yes
No

Survey
PrEP Course

more surveys
Contact Us
We welcome your comments!
[ about Smart + Strong | about POZ | POZ advisory board | partner links | advertising policy | advertise/contact us | site map]
© 2014 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.