September #105 : The Ideal Combo? - by Liz Highleyman

POZ - Health, Life and HIV
Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:

Back to home » Archives » POZ Magazine issues




Table of Contents

Kissing Babies

The Demons Behind the Down Low

Hello Our Name Is ATAC

Putting Out

The DL 411: Resources

Bedtime for Bonzo

Using My Religion

Triple Threat

Earthwatch

Dumped!

Pos & Neg

Planet Bollywood

Doing the HIV Cannes-Cannes

POZ's Bookmobile

How a Drug Becomes a Pill

Briefs

Herbs & Hard-Ons

O Sole Mio!

Quick Study: Diarrhea

The Ideal Combo?

Write On!

Trouble for Tipranavir

HIV Spoken Here

Mouth Wide Shut

Married... with Virus

Mailbox

Lady in Waiting

Publisher's Letter



Most Popular Lessons

The HIV Life Cycle

Shingles

Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV


email print

September 2004

The Ideal Combo?

by Liz Highleyman

A study claims one regimen goes with HIV—and you—like PB&J

HIV newswires recently heralded a study showing that one type of regimen rocks, packing antiviral punch and few side effects: two or three nukes—AZT (Retrovir) + 3TC (Epivir), with or without Ziagen (abacavir)—plus non-nuke Sustiva (efavirenz). Cornell’s Roy Gulick, MD, and colleagues found that the nukes-plus-Sustiva combos worked better than the nuke trio AZT/3TC/Ziagen alone—the drugs in Trizivir—regardless of baseline viral load and CD4 count. A Harvard crew saw AZT/3TC/Sustiva trump a three-drug brew of ddI (Videx) + d4T (Zerit) + protease inhibitor (PI) Viracept (nelfinavir). The star even held its own against four-drug combos; it didn’t spike body and blood fats as much as the ddI/d4T/Viracept mix did—and by starting with Sustiva, you save PIs for later, when you may need them more. (Fed guidelines list AZT + 3TC + PI Kaletra as the other top choice.)

Too good to be true? Well, folks with anxiety or depression might not choose Sustiva, which can darken the blues and cause other mental side effects such as insomnia (see “The Great Depression,” POZ, February/March 2004). Sustiva can also cause birth defects, so look elsewhere if you’re pregnant or planning to be. Finally, it reaches higher blood levels—and causes more side effects—in African Americans.

Then there’s adherence: Harvard’s Martin Hirsch, MD, says those on AZT/3TC/Sustiva must take all their meds on time—relentlessly. Single mutations can make HIV resist 3TC and Sustiva, so Hirsch says, “If adherence is likely to be a problem, consider a more forgiving regimen”—one that won’t let HIV multiply after missed doses. But the real story here is old news: One size never fits all in HIV medicine, so work with your medical team to find a treatment starring you.




[Go to top]

Join POZ Facebook Twitter Google+ MySpace YouTube Tumblr Flickr
Quick Links
Current Issue

HIV 101
HIV Testing
Safer Sex
Find a Date
Newly Diagnosed
Disclosing Your Status
Starting Treatment
Search for the Cure
POZ Stories
POZ TV
Read the Blogs
Visit the Forums
Women
African American
Latino
Providers
Job Listings
Events Calendar


    andais
    Red House
    West Virginia


    juliar33
    brooklyn
    New York


    pevans
    San Francisco
    California


    albsur7436
    San Francisco
    California
Click here to join POZ Personals!
Ask POZ Pharmacist

Talk to Us
Poll
Can social media help stop HIV stigma?
Yes
No

Survey
Mind Matters

more surveys
Contact Us
We welcome your comments!
[ about Smart + Strong | about POZ | POZ advisory board | partner links | advertising policy | advertise/contact us | site map]
© 2014 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.