November #107 : 1,2,3...ENTRY! - by Tim Murphy

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Vote '04-Who’s better for people with HIV?

Vote '04-We Have Issues

Vote '04-4 More Years?!?

Vote '04-Who Ya For?

Vote '04-Full-Frontal Election

Vote '04-Hot Seats


Back to School

When Life Hands You Lemons...

One Hot Tomato

Microbicide Update

Sayonara, Suckers

Waiting to Exhale

Pos & Neg

Fit to Print

Website of the Month


Meet Your Host


In Stores-and In Store

Brush With Nausea

Rebel With a Cause

A Woman’s Guide to Living With HIV Infection

Those Other Pills

Marijuana Mama

Found a cure

Founder's Letter


Senior Class


Inside Story

Most Popular Lessons

The HIV Life Cycle


Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

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November 2004


by Tim Murphy

HIV wends its wily way inside CD4 cells through an eerily precise three-step process. Here’s how it hppens--and how entry inhibitors stop it


HIV’s gp120 attaches to the CD4 cell’s CD4 receptor. BMS-488043, TNX-355 and PR0-542 block this step in different ways.


After gp120 has changed its shape, it binds to another receptor on the CD4 cell, called either CCR5 or CXCR4. Then gp120 changes again, moving aside to expose HIV’s harpoonlike gp41. GSK-140, UK-427 and SCH-690 all block CCR5, while AMD070 blocks CXCR4.


After gp41 embeds itself in the CD4 cell’s membrane (3A), its upper tendrils fold down and “zip” into its lower coils (3B), bringing the HIV and CD4 cell close together, then punching a hole in the CD4 cell membrane that grows until HIV empties itself into it. Fuzeon (T-20) mucks up this step.

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