September #127 : Magnum PIs: Protease inhibitor bulletin

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Table of Contents

Back to School

The Money Pit

Retro Virus


Old School

“C” Ya In Bed

Kick in the Butt

Dear Dairy

Magnum PIs: Protease inhibitor bulletin

Code Blueberry

The Porn Identity

Bye George!

Good, Dirty Fun

Deposit Slip

Blood Sport

United We Fall

U.S. Steal

A Capitol Punishment?

The Mourning Show


Hurts So Good

Editor’s Letter-Septmeber 2006

Mailbox-September 2006

Catch of the Month-September 2006

Most Popular Lessons

The HIV Life Cycle


Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

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September 2006

Magnum PIs: Protease inhibitor bulletin

Prezista and Aptivus are the latest approved members of the protease inhibitor (PI) HIV med class. Like other PIs, these cut viral loads by preventing immune cells from making more HIV, and they require a Norvir (ritonavir) booster dose. But these two may knock out some HIV that’s grown PI-resistant.

  1. Prezista (darunavir, formerly TMC-114), which won FDA approval in June, controlled HIV with a twice-daily dose, even in those who’ve taken PIs before.
  2. Aptivus (tipranavir) was approved last year for those who’ve taken combos (including PIs) before. But recently, some Aptivus takers developed bleeding in the brain. While researchers locate the cause, Aptivus should be used cautiously by anyone with risk factors for excessive brain bleeding such as high blood pressure or use of blood thinners. Red flags are up, too, for those allergic to sulfa drugs (an Aptivus ingredient). The future of the PI for those new to HIV meds is hazy: In May, a study for treatment newcomers was halted when Aptivus with a 200 mg Norvir booster was found to be liver-unfriendly, while Aptivus plus 100 mg Norvir was ineffective.

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