July / August #93 : Viread, Once A Wonder Drug - by David Gelman, MD

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Publisher's Letter



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Sex Ed’s Rubber Rubout

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On Me, Not Inn Me

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Pass The Scalpel—And The Bucks

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Cell Low, Cell High

Pillow Talk

Neg (-) But (+) For Lipo

A New Gay Plague?

Hard Workin’ Beans

Viread, Once A Wonder Drug

It's His Party

Out Of Sight

The Truth About Cats And Dogs (& A Horse And A Bird)

Getting’ Hot In Here

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Walk This Way



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The HIV Life Cycle

Shingles

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Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV


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July / August 2003

Viread, Once A Wonder Drug

by David Gelman, MD

It fights HIV! It fights hep B! No icky side effects! Too good to be true? Duh. Just when it seemed that Viread (tenofovir), Gilead’s newish nucleotide analogue, was invincible, a smattering of reports shows it can sometimes reduce kidney function (by trashing cells in the microscopic filters). This ain’t pretty (for more on kidneys, see “Hard Workin’ Beans,” above), but it’s hardly surprising—an earlier version of the drug, adefovir, failed for this very reason. And Viread includes a warning for the kidney-impaired. Happily, the problem cases improved after stopping the drug.

Kidney risk increases if you’re a woman, underweight or have taken other kidney-bashing meds. So if you’re on Viread—or considering it—make sure your doc knows that Gilead discourages those whose serum creatinine (which indicates kidney health) tops 1.5 and whose calculated creatinine clearance is below 60. All systems go? Make sure doc checks your blood and pee regularly for healthy kidney function.  




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