September #94 : Count Down - by Greg Lugliani

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Standing in the Shadows of Love

The Great Doctor / Patient Face-Off


Boy Talk

Girl Talk

Name Recognition

Dynamic Duos

Work That Visit!

It Takes a Villager


Devil in a Blue Dress

U.S. Armed Cervixes

Cell Culture


Class Act

Good Book

Rape OutRAGE

It Happened in September

Hitting the Switch

Missed Doses


Count Down

Tailgating HIV


Potty Mouth

Booty Call

London Calling

Test Drive

Aid for Medicaid

Editor's Letter

Lei'd in the Shade

The Wings Beneath His Wind

Most Popular Lessons

The HIV Life Cycle


Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

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September 2003

Count Down

by Greg Lugliani

New classes of antiretrovirals aren’t gushing out of the pipeline today, but you can spot plenty of old stand-bys in new get-ups. The latest makeover: Agouron’s buff, 625-mg update of its protease inhibitor, nelfinavir (Viracept). FDA-approved in April, it slashes the 250-mg version’s pill count—from 10 to four—with the same twice-daily dosing.

Fewer pills can mean better adherence, and that’s grand. But some pipeline insiders worry that the new version may cause even more diarrhea than its bowel-loosening predecessor because of its greater bioavailability (how much of, and how fast, your body can process a substance). Richard Ogden, Agouron’s senior director of scientific development, told POZ their research shows “no increase in the frequency of diarrhea” at higher doses.

The new model joins the old on shelves this fall, and Ogden says many patients will be advised to switch. Only HIVers who do so will be able to tell if the new pill is the charm—or the Charmin.

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