July / August #83 : Defensive Tackle

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Table of Contents

Once Upon A Time...

Young At Heartland

The Lying Game

Life vs. Meth

This Is Only a Test

Mbeki's 180

Spin Doctors

Soda Wars

Iran Runs

New Friend

Sex Crimes

Got Milk? Get Meds

Got His Goat

Monkey C

Mind Trip

Beach Reads

Memory Lane

Face the Music

Failure Is Sweet

Who Done It

Defensive Tackle

Under the Sun

Cave Kava

Relayed Reaction

Habit Helpers

Ticked & Stoned

Rated X5

Vax Populi

TB or Not TB

IV Leader

Flower Children


Drug Interactions

Dubya Trouble

Publisher's Letter


Reed Represents

Most Popular Lessons

The HIV Life Cycle


Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

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July / August 2002

Defensive Tackle

Oh, that little mind-game of a virus. Just when it seemed that a structured treatment interruptio

Oh, that little mind-game of a virus. Just when it seemed that a structured treatment interruption (STI) might give the immune system a chance to deck the virus on its own, we discover that the minute HIV rebounds in someone off HAART, it heads straight for the very HIV-specific CD4 cells that are the first line of defense against the virus. That's the take-home from new work by the NIH Vaccine Research Center's Daniel Douek, MD, PhD, and colleagues, who reported in a recent issue of Nature that, though the virus is an equal-opportunity attacker of CD4 cells when it rebounds, it gives special treatment to those specifically charged with bashing HIV. In other words, the more CD4 cells you made while on meds, the more for the bugger to infect when you go off. So are STIs RIP? Not at all, sayeth Douek: Short-term -- one-week-on, one-week-off -- drug breaks can still cut side effects, toxicity and costs in half while keeping the virus from taking off. Moral of the story? As Douek told Reuters Health: "We must not tarnish all STIs with the same brush."

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