October #85 : No Guest List - by Clarinda MacLow

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Table of Contents

Tough Act to Swallow

Worlds Collide

Alone on the Range

Two-Timin' Man

New Head, Same Hydra?

Mup Roar

Land of Oz

Merger Mania

AZT Fraud?

Off The Cuffs

Red Scare

Hardish Times

Fatwa Skinny

What's In A...?

Epis Appeal

Mining for Meaning

Losing Control

No Guest List

Hep Hooray

Home Remedy

Did You Hear?

Status Seeking

Editor's Letter



Sins of Transmission

Porn Again

Most Popular Lessons

The HIV Life Cycle


Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

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October 2002

No Guest List

by Clarinda MacLow

Burly bouncers like the protease inhibtors stop HIV from spoiling all the fun at Studio CD4, but why not hire bad-ass doormen to keep undesirables out da club in the first place? That's the idea behind fusion inhibitors, like the soon-to-market T-20. Now flutter your lashes at the chemokine antagonists, which latch onto the CD4 shell to smack down wildin' HIV before it can crash the party. CAs up for the glamor job include Schering-Plough's SCH-D, Progenics' PRO 140 and PRO 542 and AnorMED's AMD-070, already through early trials. Meanwhile, the ragtag army of HIV R&D is still managing to find new ways to control the riot inside: integrase inhibitors, say, and new non-nukes, including the rain-forest plant calanolide A; a rehabbed capravirine (vasculitis froze the prior's canine trials); and DPC083 (think Sustiva with a longer half-life).

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