August #73 : On an Off Trial - by Mike Barr

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Table of Contents

Gimme A Break!

Too Close for Comfort

On an Off Trial

Publisher's Letter

Mailbox

Got Asylum?

Dogma Doo

Bad Ad Fad

Highest Court On Weed

Obit: Robert C. Randall

The Tour de France

Center Stage

Drama Queens

Lipo Ladies

Her So Good

Playing for Time

Herb Blurb

Hurry Up, PEP, It’s Time!

Is Less More in Safe-Sex Ed?

Combo Condom

Pregger Rap

Pocket Money

Good Company

20 Years And Counting

Missing in Action

Memo From Hell

Material Girl

Snap Shots: Joe Westmoreland



Most Popular Lessons

The HIV Life Cycle

Shingles

Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV


email print

August 2001

On an Off Trial

by Mike Barr

Itchin' to take a drug break? Wanna add to collective STI knowledge? Check out one of these cl

Itchin' to take a drug break? Wanna add to collective STI knowledge? Check out one of these clinical trials studying treatment interruptions and intermittent ("pulsed") therapy.

AACTG 5024
TRIAL: Compares STI w/ IL-2, w/ ALVAC vaccine or with both vs. w/o
CRITERIA: On stable antiretroviral therapy for six months; CD4s > 350; viral load < 50
STATUS: 64-week study; currently enrolled 41 out of 100
CONTACT: Multiple sites, 800.TRIALS.A

AACTG 5068
TRIAL: Compares STI w/ vs. w/o use of ALVAC vaccine
CRITERIA: On first combination regimen; CD4s > 500 for at least 6 months; viral load < 50
STATUS: 24-month study; currently enrolled 7 out of 100
CONTACT: Multiple sites, 800.TRIALS.A

AACTG 5086
TRIAL: Compares immediate vs. deferred (four-month STI) treatment in salvage situation
CRITERIA: Drug-resistant HIV; CD4s > 150; "high" viral load
STATUS: 64-week study; currently enrolled 3 out of 220
CONTACT: Multiple sites, 800.TRIALS.A

AACTG 5102
TRIAL: Compares STI w/ vs. w/o use of IL-2
CRITERIA: No history of drug failure; no steroids; CD4s > 500; viral load < 200
STATUS: Still in development; 80 slots
CONTACT: Multiple sites, 800.TRIALS.A

Cornell/New York Hospital
TRIAL: Compares STI w/ vs. w/o use of IL-2, ALVAC or the two together
CRITERIA: On stable antiretroviral therapy for six months; no hepatitis B or C; CD4s > 400; viral load < 50
STATUS: 25-week study; currently enrolled none out of 92
CONTACT: 212.241.6886

CPCRA 064
TRIAL: Compares immediate vs. deferred (4-month STI) treatment in salvage situation
CRITERIA: Drug-resistant HIV; viral load > 10,000; also enrolls adolescents (> 13 yrs)
STATUS: 24-month study; currently enrolled 150 out of 480
CONTACT: Multiple sites, 800.TRIALS.A

CPCRA "SMART"
TRIAL: Compares continuous vs. on/off treatment strategies
CRITERIA: CD4s >350; also enrolls adolescents (> 13 yrs)
STATUS: Still in development; enrollment set for October 2001
CONTACT: Multiple sites, check www.smart-trial.org

Gladstone/UCSF
TRIAL: Compares continuous vs. intermittent treatment (six months on, two months off)
CRITERIA: On stable antiretroviral therapy; pre-treatment CD4 low > 100; viral load < 50 for at least 3 months
STATUS: 24-month study; currently enrolled 10 out of 20
CONTACT: 415.695.3820

NIH I-0020
TRIAL: Compares continuous vs. intermittent treatment (two months on, one month off)
CRITERIA: CD4s > 300; viral load < 50
STATUS: 22-month study; currently enrolled none out of 70
CONTACT: 800.411.1222

Wistar/U Penn
TRIAL: Compares continuous vs. intermittent treatment, followed by unlimited STI
CRITERIA: CD4s > 400; viral load < 100 for 3 years
STATUS: 56-week study; currently enrolled 20 out of 52
CONTACT: 215.985.4448, ext. 226




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