November #76 : Heart Smart? - by Lark Lands

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Masters of Disasters

Out of the Chaos, Voices

The Mighty ACT UP Has Fallen: The Philadelphia Story

Hit Me, Baby, One More Time

Final Chapters

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Hope Screens Eternal

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New Drug Watch: Tenofovir

The Real Female Rubber

Twice Bitten

SAY WHAT?

Curve Ball

Heart Smart?

Darkness at Noon

Stranger in a Strange Land

Editor's Letter

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The Face of Terror



Most Popular Lessons

The HIV Life Cycle

Shingles

Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV


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November 2001

Heart Smart?

by Lark Lands

Fears of future ticker trouble may put atazanavir, Bristol-Myers Squibb's new once-daily protease inhibitor (PI), on the top of many HIVers' check-it-out lists. With the current PIs, skyrocketing triglycerides and cholesterol readings are way too common, but in a 48-week study of treatment-naive HIVers in Argentina, blood fats remained normal in those on atazanavir combined with the nukes d4T (Zerit) and 3TC (Epivir). Those given the same nukes with nelfinavir (Viracept) saw quick and sustained jumps in triglycerides, total cholesterol and LDL cholesterol (the bad kind) -- all of which increase the risk for cardiovascular disease. As a nice bonus, only 13 percent of the atazanavir users had diarrhea compared to more than half of those taking nelfinavir. Although not yet approved, atazanavir may soon be available through an expanded-access program.




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