August #50 : Viagra, Poppers and... - by Lark Lands

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Table of Contents

Bug Bugaboo

The Universe, Concealed

The Curious Closets of Barton Benes

Trailblazer

Net Serve

Catching Up With...

S.O.S

To the Editor

Court to Mom: “Don’t Milk It”

HIV Tat Spat

Livin' la Vida Loca

Heaven’s Gates

Say What

No Sharp Shooter

Squibb’s Dibs

Tooth Fairy

Meds Downed in Lockup

Coming Attraction

POZ Picks

Enigma of the People

Thymus of the Essence

The AIDS-Friendly HMO

Someone's in the kitchen with...

Thorne on Our Side

Obits

The Bully

A Spy in the House of Love

Is the Crisis Over?

Get Over It

More on the Nuke-Lipo Link

Viagra, Poppers and...

60 Years!?!

Toot the Hormone

Penny Pincher

Smear Campaign

Loading Zone

See Emily Play

Shagalicious Shaw



Most Popular Lessons

The HIV Life Cycle

Shingles

Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV


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August 1999

Viagra, Poppers and...

by Lark Lands

The red flag is up for those protease-takers who use Viagra (sildenafil) to get it up. The problem is that all five PIs inhibit the CYP 3A4 liver enzyme that breaks down the potency pill. This causes more Viagra to remain in the blood longer and to produce worse side effects, including abnormal vision, flushing, headache and drops in blood pressure. In a study by Viagra’s manufacturer, Pfizer, even the slightest inhibitor of CYP 3A4, saquinavir (Invirase), increased the maximum Viagra concentration in the blood by 140 percent, while the strongest inhibitor, ritonavir (Norvir), increased it by 400 percent. Pfizer now recommends that for anyone on a PI, the standard 50-milligram Viagra dose should be halved, and that no one on ritonavir should repeat the drug in fewer than 48 hours (24 hours for those on any other PI). And those seeking to spice up Viagra-spiked sex with a side of poppers (amyl or butyl nitrate) should beware: Since both Viagra and poppers cause blood vessel dilation, the combo can cause serious—even fatal—blood pressure decreases.



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