October #52 : Nuking it Out - by Lark Lands and Edited by Bob Lederer

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Love Me Gender

21st Century Vax

How to get There From There

Fear of a Vax Planet


Letters to the Editor October 1999

The End of an Epidemic?

General Delivery

Veep Show

Black Is...Black Ain't

Memo for the Millennium

Addicted to Life

The Club Scene

Get Over It

Nuking it Out

Babes Out of the Woods

A Vicious Cycle

First Things First

On the Cutting Edge

Great White Hope

Northern Light

I Sing The Body Electric

Most Popular Lessons

The HIV Life Cycle


Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

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October 1999

Nuking it Out

by Lark Lands and Edited by Bob Lederer

Often called the energy factories inside cells, mitochondria may suffer damage from nucleoside analogs, new research by a Dutch investigator suggests. According to Kees Brinkman, MD, PhD, this may explain many of the nukes' side effects--neuropahty, myopathy (muscle damage), pancreatitis, lowered blood counts and lactic acidosis, a dangerous buildup of lactic acid in the blood. As if that's not enough, Brinkman theorizes that mitochondrial toxicity could also play a key role in lipodysotrophy, which has recently been linked to nuke usage (see POZ, Big Science, August 1999). Test-tube studies showed that the level of toxicity is, in descending order, ddC, d4T, and then AZT and ddl in a tie. Adrefovir, a nucleotide analog, also damaged the mitochondria. Only 3TC appearde to leave them unscathed.
Brinkman plans to study the possibility of preventing or reversing nuke side side effects, including lipodystrpohy, with nutrients that have been shown to sometimes help reserve hereditary mitochondria dysfunction: L-cartine, the amino acid shown in earrlier research to treat AZT-induced myopathy, riboflavin (a B vitamin), coenzyme Q-10 (an accessory nutrient) and possibly vitamin E and other antioxidants. 

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