October #52 : A Vicious Cycle - by Lark Lands and Edited by Bob Lederer

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Table of Contents

Love Me Gender

21st Century Vax

How to get There From There

Fear of a Vax Planet


Letters to the Editor October 1999

The End of an Epidemic?

General Delivery

Veep Show

Black Is...Black Ain't

Memo for the Millennium

Addicted to Life

The Club Scene

Get Over It

Nuking it Out

Babes Out of the Woods

A Vicious Cycle

First Things First

On the Cutting Edge

Great White Hope

Northern Light

I Sing The Body Electric

Most Popular Lessons

The HIV Life Cycle


Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

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October 1999

A Vicious Cycle

by Lark Lands and Edited by Bob Lederer

Plan A for suppressing HIV in the heavily treatment-experienced has generally meant mega-HAART regimens, a smorgasbord of five to nine drugs that can cause serious side effects, a huge pill burden and a scheduling nightmare. Searching for an effective Plan B led Spanish researchers to "cyclic" therapy, in which two different three- to four-drug regimens are alternated monthly. The theory sounded good: About the time resistance-creating mutations begin to develop against one regimen, a switch is made to the other. Indeed , six of the 11 PWAs who completed 24 weeks of therapy achieved undetectable viral loads. But more than a third of the participants withdrew because of side effects, which tend to be most problematic in the first few weeks of therapy. Since this approach switches the drugs every four weeks, the body has to readjust constantly. The result seems to be unacceptable symptoms in many. Plan C anyone?

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