April #34 : Brain Gain

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Table of Contents

Faith, Hope and Monica

Vintage Gallo

Silence=Deaf

At the End of the Pier

Mourning Becomes Montero

Baby Love

Chris Crossed

Faith Healing

Do Tell

What This Means: Have Mass, Will Travel

Money: Fine Whines

Less is More

POZ Picks: The Complete Bedside Companion

POZ Verse: Fever

At the End of the Pier

Coming soon to a theater near you

Daytime Trauma

Even Good Boys Do Fail

Relishing Our Time

Killing Me Softly

S.O.S.

Obits

Say What

Shalala Infections

The Fraud Squad

Reefer Badness

Brain Gain

Pipeline Dreams

Virtual Activism

Fruit Loops

What's Cookin'?

United Way

La Bomba

War-Torn Nation



Most Popular Lessons

The HIV Life Cycle

Shingles

Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV


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April 1998

Brain Gain

The power of protease thinking

Protease inhibitors may help stop -- and even reverse -- AIDS dementia, according to Dr. Christopher Filippi of New York City's Albert Einstein College of Medicine. Citing his study of 16 end-stage PWAs -- nine on protease inhibitors and seven not -- Filippi said that protease-based combinations "reversed dementia in some cases, and that's never been shown before." Of the nine on protease, all but one had a reduction in dementia; four stabilized to near normal. Several patients who had been nurse-dependent even went back to work, Filippi said.

The patients not on protease? "They got more demented," Filippi said. "The brain scans got much worse and over the next six months almost all of them died." Dr. Richard Price, professor of neurology at the University of California San Francisco, trumpeted his colleague's work. "Most people interested in AIDS dementia have the sense that antiretroviral therapy does help these patients," he said. "The only issue is which combinations are most effective." The number of dementia cases is apt to decrease with time, Filippi predicted, since most PWAs are now routinely started on protease inhibitors. But, he pointed out, many who live in rural regions do not have access to the drugs.




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