November #41 : Draining the Reservoirs - by Lark Lands

POZ - Health, Life and HIV
Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:

Back to home » Archives » POZ Magazine issues




Table of Contents

Organizing Inside

Concealed Weapon

Long Day's Journey

Lethal Lottery

Natural Bootleg

Double-Crossed

One for the Books

Flying Ace

Tucker: The Man and His Dream

Hatch a Plan

Signs of Life

The Trouble With Norvir

Engine No. 48,000

S.O.S.

To the Editor

None the Wiser

Tomato, Tomahto

Enter at Your Own Risk

Say What

Swim Lessons

Stigma Enigma

Daddy’s Helper

Nushawn on the Block

Privacy Parsed

Equal Protection for All

“Just Say No” to Welfare

Ms. Thurman Goes to Washington

POZ Picks

Show and Tell

The Eye in the Storm

Get Our Phil

POZarazzi: AIDS! The Musical

Verse: Amirah

Obits

One for the Books

Flying Ace

Tucker: The Man and His Dream

Hatch a Plan

Poetic License

Poetic License

The Vision Thing

Stop the World, I want to Get Off

Surviving Behind the Walls

Prick and Tell

The Bitter End

Draining the Reservoirs

Testosterone Beats Fatigue

Carnitine Boosts CD4s

Multivitamins for Moms

Bleach Works

HIV Med Line

Weight List

Do the Hustle

A Mantra a Day

Attack of the Monster Combo

Helper Cells

He Still Is What He Is

Dark Secrets



Most Popular Lessons

The HIV Life Cycle

Shingles

Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV


email print

November 1998

Draining the Reservoirs

by Lark Lands

It’s clear by now that crafty HIV infiltrates a variety of hidden “reservoirs” in the body. A team at the National Institutes of Health (NIH) has taken what Anthony Fauci, MD, the director of the National Institute of Allergy and Infectious Diseases, calls a “tiny step” toward discovering how to drive HIV out of its hiding places and into the bloodstream, where it’s vulnerable to antiretroviral drugs. 

Fauci and his colleague Clifford Lane, MD, looked at the possibility that infusions of interleukin-2 (IL-2),  long studied as an immune modulator that boosts CD4 counts, might wake up resting immune cells and flush out elusive HIV. They compared culture results of peripheral blood mononuclear cells (PBMCs) from 26 patients whose viral loads had become undetectable while on highly active antiretroviral therapy (HAART). Thirteen of the patients had also been receiving IL-2 infusions for an average of 39 months in doses of 3 to 18 million units daily, given for five days in a row, followed by at least eight weeks off the drug.

Virus could be cultured from the PBMCs of all patients on HAART alone. However, even using an analysis that assessed over 300 million cells, virus could not be isolated from PBMCs taken from three of those also on IL-2. But Fauci cautions that this does not mean that those patients are completely HIV free. He says there are many body compartments where HIV can hide—including lymphoid tissue, the brain, the bone marrow, and the testes—which weren’t assessed. And he strongly emphasizes that this is very preliminary. “The only real proof of pudding will be what happens when you stop all therapy in these people to see if virus can then be found.”

Lane is beginning a separate trial in which patients with long-term undetectable viral loads will stop all antiretrovirals. By tracking them with a variety of assays, he hopes to discover whether drug holidays are possible for some PWAs, at least for a period of time, and which assays might predict who could do well with drug cessation.




[Go to top]

Join POZ Facebook Twitter Google+ MySpace YouTube Tumblr Flickr
Quick Links
Current Issue

HIV Testing
Safer Sex
Find a Date
Newly Diagnosed
HIV 101
Disclosing Your Status
Starting Treatment
Help Paying for Meds
Search for the Cure
POZ Stories
POZ Opinion
POZ Exclusives
Read the Blogs
Visit the Forums
Job Listings
Events Calendar


    aqua_31206
    Macon
    Georgia


    Loveladyd
    Washington
    DC


    Sexynyrican
    Brooklyn
    New York


    jap022964
    el dorado
    Arkansas
Click here to join POZ Personals!
Ask POZ Pharmacist

Talk to Us
Poll
Do you work with your doc to design your own treatment regimen?
Yes
No

Survey
PrEP Course

more surveys
Contact Us
We welcome your comments!
[ about Smart + Strong | about POZ | POZ advisory board | partner links | advertising policy | advertise/contact us | site map]
© 2014 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.