Choose from two basic STI timetables. The first: staying off meds until lab numbers or illness require restarting. Sax calls this the safest, adding that he prefers using lab results, not “waiting for symptoms” to signal the end of the holiday.
More controversial: intermittent therapy. Montaner says, “More times on and off make sustaining viral suppression less likely.” Says Kaiser: “This is a prescription for breeding resistance.”
Intermittent therapy comes in several patterns, including the convenient “weekend” version: five days on meds, two off. But results are mixed. In a six-month study, Cohen found that this pattern worked well for HIVers on non-nuke combos, while some on protease combos had viral rebounds.