June #124 : Tart Up Your PI - by Laura Whitehorn

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Table of Contents
 

Jazzed

Mentors-June 2006

A Growing Concern

Cover Q&A-June 2006




Supplemental Insurance

Oral Thursh Knockout

Med-Mix Warning

Chow, Babe

Tart Up Your PI

Food for Oil

Fatty Acid Trip

In the Key of Life

PREP School

PREP for the future

WAL-MART Special

Bush the Builder

The Domino Effect

Happy Birthday to Us




Can NYC Keep A Lid On AIDS?

Virgin Vaccine

Onward Christian Condoms

Earthwatch

Raining Men

Positive Change

Growing Pains

Dolled Up

That ’80s Show

I See Dead People




Editor's Letter-June 2006

Mailbox-June 2006



Most Popular Lessons

The HIV Life Cycle

Shingles

Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV



email print

June 2006


Tart Up Your PI

by Laura Whitehorn

Could a grapefruit juice compound squeeze out Norvir’s boost?

Using a low, 100 mg dose of the protease inhibitor Norvir (ritonavir) to boost other PIs is now standard in HIV treatment. The subtherapeutic booster doesn’t stop HIV from reproducing, but it does block an enzyme in your gut and liver, allowing other PIs in your combo to loiter longer and work better. But the added Norvir can cause gut problems and increase blood fats and sugars.

Bioavailability Systems, a small research company, has developed a booster substitute from a grapefruit-juice compound, hoping to cause fewer side effects. (The levels of PI-boosting compounds in actual grapefruit juice are variable and unpredictable, so PI takers are warned not to drink the stuff.) A company spokesperson told POZ that he didn’t know when the product, called BAS-100 for now, might be available (early human trials have showed good results; find summaries at www.bioavailsys.com/ClinicalTrials.htm). Despite its bland name, he calls BAS-100 “kickass.” We’ll need more data before we’re similarly juiced.            



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