Treatment News : Potential Microbicide Tricks HIV Into Sudden Death

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October 10, 2013

Potential Microbicide Tricks HIV Into Sudden Death

Joining the crop of investigational anti-HIV agents that attack the virus before it can enter immune cells, a new potential microbicide element tricks HIV into expelling its DNA before latching onto a human cell, thus prompting a benign death. Publishing their findings in Antimicrobial Agents and Chemotherapy, researchers at Drexel University engineered a molecule from segments of other molecules in order to create a dual action virolytic entry inhibitor, or DAVEI.

In order for HIV to infect a human immune cell, it must first fuse to the outside of the cell before inserting its genetic code. The scientists set out to create a molecule that would create a facsimile of this process. One segment of the molecule, known as the membrane proximal external region, is a portion of cellular fusion machinery and has a propensity to interact powerfully with the membranes of the virus. A second segment of the DAVEI is a cyanovirin, which connects to the sugar coating over the spikes on HIV’s surface that the virus uses to attach to human cells.

“For lack of a better term, DAVEI tricks the virus into thinking it is about to infect a healthy cell, when, in fact, there is nothing there for it to infect,” Cameron Abrams, PhD, a professor in Drexel’s College of Engineering and the study’s principal investigator, said in a statement. “Instead, it releases its genetic payload harmlessly and dies.”

To read the Vaccine News Daily story, click here.

To read a release on the study, click here.

To read the study abstract, click here.

Search: HIV, dual action virolytic entry inhibitor, DAVEI, Drexel University, microbicide, cyanovirin, membrane proximal external region, Cameron Adams.

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  comments 1 - 3 (of 3 total)    

being human, darnestown, 2014-07-22 23:59:41
sounds like that drug called sulferson. it was a sulfer coated with a simple sugar. thus tricking the body to accept the camo - sulfer .it was for people that were alergic to sulfer based drugs. the company went bankrupt.

JT, , 2013-10-18 12:10:57
All well and good. But what happens to the "man-made" molecule that is now carrying the "genetic payload" from the dying HIV virus? Can someone who is familiar with this discovery answer that question, please?

Joel, Corona, Ca, 2013-10-15 21:04:16
Wow that is amazing how scientists can manipulate the HIV

comments 1 - 3 (of 3 total)    

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