Treatment News : Failure to Awaken Dormant Cells Deals Blow to HIV Cure Research

POZ - Health, Life and HIV
Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:

Back to home » Treatment News » March 2014

Most Popular Links
Most Popular Lessons

The HIV Life Cycle

Shingles

Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

15 Years Ago In POZ


More Treatment News

Click here for more news

Have news about HIV? Send press releases, news tips and other announcements to news@poz.com.


emailprint

March 31, 2014

Failure to Awaken Dormant Cells Deals Blow to HIV Cure Research

CROI 2014A laboratory at Johns Hopkins University has failed in its recent quest to find a drug that can reverse the latent state of HIV-infected immune cells that are a component of the viral reservoir. Publishing their disappointing results in Nature Medicine, researchers drew white blood cells from people with HIV and tested drugs known as HDAC inhibitors on latently infected cells.

“Despite our high hopes, none of the compounds we tested in HIV-infected cells taken directly from patients activated the latent virus,” Robert F. Siliciano, MD, PhD, a professor of medicine at the Johns Hopkins University School of Medicine and the study’s senior author, said in a release.

The study’s findings call into question whether it will be possible to flush HIV out of dormant cells with a latency-reversing agent. HIV can remain in these cells because the cells do not replicate at a level that produces certain proteins that would alert the immune system to their presence. Nor can antiretroviral (ARV) treatment attack a cell that is dormant. Thus, the virus can remain there untouched and can replenish the viral population in the event that ARV treatment is stopped. A possible route to a cure with HIV, in theory, would involve flushing HIV out of all these cells.

The study did yield advancements in scientific knowledge nevertheless. The researchers were able to develop more sensitive tests to detect reactivation of HIV. They also determined that the HDAC inhibitors studied increased viral RNA production mostly by a one- to two-fold rate, with one drug upping the viral production six- to 10-fold. Considering that a virus-producing cell would have about a 100-fold increase in viral RNA production, the researchers now intend to study combinations of the HDAC inhibitors in hopes that together they might raise the rates of increased viral RNA production.

To read the press release, click here.

To read the study abstract, click here.

Search: Johns Hopkins, cure research, HIV, failure, disappointing, latently infected cells, Nature Medicine, HDAC inhibitors, Robert Siliciano.


Scroll down to comment on this story.



Name:

(will display; 2-50 characters)

Email:

(will NOT display)

City:

(will display; optional)

Comment (500 characters left):

(Note: The POZ team reviews all comments before they are posted. Please do not include either ":" or "@" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules



Show comments (1 total)

 
[Go to top]


Join POZ Facebook Twitter Google+ MySpace YouTube Tumblr Flickr
Quick Links
Current Issue

HIV Testing
Safer Sex
Find a Date
Newly Diagnosed
HIV 101
Disclosing Your Status
Starting Treatment
Help Paying for Meds
Search for the Cure
POZ Stories
POZ Opinion
POZ Exclusives
Read the Blogs
Visit the Forums
Job Listings
Events Calendar


    dambitious
    Gone
    New York


    newlife202
    JOLIET
    Illinois


    usuallyhappy
    Palm Springs
    California


    humboman
    Baltimore
    Maryland
Click here to join POZ Personals!
Ask POZ Pharmacist

Talk to Us
Poll
Is HIV/AIDS adequately portrayed in pop culture?
Yes
No

Survey
Pop Watch

more surveys
Contact Us
We welcome your comments!
[ about Smart + Strong | about POZ | POZ advisory board | partner links | advertising policy | advertise/contact us | site map]
© 2014 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.