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May 2008
Protein Shakers
Proteins aren’t important just in your diet. More than 100,000 of them help your body’s cells do what they do—and some are providing the basis for future HIV meds.
Researchers recently identified 273 proteins that HIV uses as stepping-stones to infect and reproduce in the body. Once scientists ID them, they can study each
protein to see how it enables the virus. Meet three that have been getting attention—and learn how they can help you.
Name
| Job
| Drug Contribution
|
CCR5
| Acts as a lock on immune cells that HIV must pick before entering
| Heped produce entry-inhibitor HIV meds, which block CCR5 so the virus can't get into a T cell |
APOBEC36
| Can protect immune cells from infection--provided that an HIV protein ("vif") doesn't interfere
| Understanding APOBEC3G's natural HIV-fighting ability--and its interaction with vif--may produce a slew of new drugs. |
P13K/Akt
| Runs a pathway in cells that prevents infected ones from self-destructing (for your body to heal, this cellular suicide is neccesary)
| Has already helped produce a drug that allows parasite-infected cells to die off. That druge, miltefosine, is being studied to see if it will work against HIV, too.
|
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