May #144 : Protein Shakers

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Table of Contents

HIV: Behind the Music

Taking Care of Business

Not by Meds Alone

No Viral Load=No Transmission?

The Stand

Staphing Up


Heads of the Class

Heartburn Hotel

Protein Shakers

Mercury Rising

Britain: Hep C Rings Twice

Pill-Taking Tip

Cardio Risk Raiser

Cholesterol Downer

What's a Girl to Do?

Runaway Hit

The Mother of All HIV Tests

Lights! Camera! Bareback Action!

Prom Night Prep

Apply as Directed

Strong-arming HIV

Healing Fields

Jargon: DWI

Keeping Up With the Joneses

Melrose Place 2.0


Rock Out

Ladies First

Editor's Letter-May 2008

Mailbox-May 2008

Most Popular Lessons

The HIV Life Cycle


Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

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May 2008

Protein Shakers

Proteins aren’t important just in your diet. More than 100,000 of them help your body’s cells do what they do—and some are providing the basis for future HIV meds.

Researchers recently identified 273 proteins that HIV uses as stepping-stones to infect and reproduce in the body. Once scientists ID them, they can study each protein to see how it enables the virus. Meet three that have been getting attention—and learn how they can help you.

Name: CCR5
Job: Acts as a lock on immune cells that HIV must pick before entering
Drug Contribution: Heped produce entry-inhibitor HIV meds, which block CCR5 so the virus can't get into a T cell

Name: APOBEC36
Job: Can protect immune cells from infection--provided that an HIV protein ("vif") doesn't interfere
Drug Contribution: Understanding APOBEC3G's natural HIV-fighting ability--and its interaction with vif--may produce a slew of new drugs.

Name: P13K/Akt
Job: Runs a pathway in cells that prevents infected ones from self-destructing (for your body to heal, this cellular suicide is neccesary)
Drug Contribution: Has already helped produce a drug that allows parasite-infected cells to die off. That druge, miltefosine, is being studied to see if it will work against HIV, too.

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