Treatment News : Post-Exposure Microbicide Gel Shows Promise in Monkeys

POZ - Health, Life and HIV
Subscribe to:
POZ magazine
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join

Back to home » Treatment News » March 2014

Most Popular Lessons

The HIV Life Cycle


Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

20 Years Ago In POZ

More Treatment News

Click here for more news

Have news about HIV? Send press releases, news tips and other announcements to


March 14, 2014

Post-Exposure Microbicide Gel Shows Promise in Monkeys

An Isentress (raltegravir)-containing microbicide gel prevents vaginal transmission of the simian cousin of HIV, SIV, when used as a post-exposure prophylaxis (PEP), The New York Times reports. Publishing their findings in Science Translational Medicine, researchers sought an alternative to the traditional reverse transcriptase inhibitors as an active ingredient in microbicides. They theorized that, because integrase inhibitors attack the virus during a later phase in its life cycle, a microbicide containing an antiretroviral from this drug class could be used after sex instead of before. Furthermore, unlike the common microbicide ingredient Viread (tenofovir), which must undergo chemical changes in the body before it can be effective in fighting the virus, integrase inhibitors act immediately.

First the researchers determined that the virus conducts the integration phase of its life cycle about six hours after infecting a cell, thus theoretically opening a window of time during which to introduce an integrase inhibitor.

Then the researchers applied a vaginal microbicide gel containing the integrase strand transfer inhibitor L-870812 to three macaque monkeys 30 minutes before a vaginal exposure to SIV. Two of the three monkeys were protected from transmission.

Next they used a gel containing a 1 percent concentration of the integrase inhibitor Isentress. Applied three hours after vaginal exposure to SIV, this gel protected five out of six of the monkeys against the virus. All monkeys receiving a placebo gel contracted SIV.

The researchers were unable to determine the reason why the two monkeys in the respective study groups became infected.

The researchers concluded that the study provided a proof of concept that a PEP application of a microbicide gel containing an integrase inhibitor could protect against SIV when applied within three hours of vaginal exposure to the virus.

To read the New York Times story, click here.

To read the study abstract, click here.

Search: Microbicide, Isentress, raltegravir, SIV, HIV, monkeys, post-exposure prophylaxis, PEP, Viread, tenofovir, integrase inhibitor, The New York Times, Science Translational Medicine.

Scroll down to comment on this story.


(will display; 2-50 characters)


(will NOT display)


(will display; optional)

Comment (500 characters left):

(Note: The POZ team reviews all comments before they are posted. Please do not include either ":" or "@" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules

Show comments (0 total)

[Go to top]

Facebook Twitter Google+ MySpace YouTube Tumblr Flickr Instagram
Quick Links
Current Issue

HIV Testing
Safer Sex
Find a Date
Newly Diagnosed
HIV 101
Disclosing Your Status
Starting Treatment
Help Paying for Meds
Search for the Cure
POZ Stories
POZ Opinion
POZ Exclusives
Read the Blogs
Visit the Forums
Job Listings
Events Calendar
POZ on Twitter

Ask POZ Pharmacist

Talk to Us
Did you participate in an event for National Black HIV/AIDS Awareness Day 2016?


more surveys
Contact Us
We welcome your comments!
[ about Smart + Strong | about POZ | POZ advisory board | partner links | advertising policy | advertise/contact us | site map]
© 2016 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.