January 25, 2013
Stanford’s Gene Therapy Helps Block HIV’s Ability to Bind to CD4s
In a step forward for genetic therapy research, scientists at Stanford University School of Medicine have created an advanced method of engineering CD4 cells to resist HIV infection, the San Francisco Chronicle reports. Ongoing research conducted by Sangamo BioSciences and the University of Pennsylvania has used gene therapy to effectively block the CCR5 receptor on the surface of CD4 cells to which HIV latches in order to ultimately gain entry into the cell. Building on that model, the Stanford study has gone further by creating another splice in the CCR5 receptor’s DNA and adding two additional genes—a method known as stacking. Consequently, the total of three synthetic genes helped prevent HIV’s entry into the cells through either the CCR5 or CXCR4 receptors. Their results were published in the journal Molecular Therapy.
The researchers tested their gene therapy in a laboratory setting (not in humans), inserting one, two or all three of the genes into CD4 cells before exposing them to the virus. Those cells that were exposed to either one or two gene modifications were somewhat protected against infection. But those that received the triple modification had more than a 1,200-fold protection against HIV molecules that use the CCR5 receptor for entry—called being “CCR5-tropic”—and a 1,700-fold protection against the CXCR4-tropic viruses.
In a statement, Matthew Porteus, MD, an associate professor of pediatrics at Stanford, said such tailored gene therapy could one day replace daily antiretrovirals as a treatment for HIV. However, actual human trials aren’t expected for another five years.
To read the Stanford statement, click here.
To read the San Francisco Chronicle story, click here.
Search: Stanford Medical School, HIV, CD4, CCR%, CXCR4, Molecular Therapy, University of Pennsylvania, San Francisco Chronicle, Sangamo BioSciences, Matthew Porteus, receptor.
Scroll down to comment on this story.
comments 1 - 15 (of 15 total)
mborovets, Kyiv, 2013-05-30 17:19:05
Similar trial showed infused stem cells don't live long enough in human body. They disappeared after one year. google "hiv OZ1". The main producer of blood cells is still marrow bone with larger quantity of stem cells than could be infused. that is why the Berlin patient experience is not repeatable with infusion of stem cells.
Steve S., Baltimore, 2013-02-26 10:29:25
Excellent news. Please keep the research coming!
Ranjan, , 2013-02-19 21:02:06
Anything that is 5 years away from even human trial is not even worth mentioning and only raises false hopes. Must one play with emotions of those affected
xavier, edmore, 2013-02-17 15:49:35
I would be interested in human trials when the time comes.
Andy, Cleveland, 2013-02-13 11:55:54
"Where are the ACT UP member who who chain themselves to the door of FDA and demand this and other potential cures be expedited!"
They're nude, in Boehner's office, demanding that the govt continue to write blank checks to Big Pharma. Those of us who are HIV+ need to look in the mirror and ask what we are really working for before we start wondering why cure research is stagnant. Most "activists" are underpaid pharmaceutical reps. It doesn't have to be this way. Real change starts at home.
Big-D, Los Angeles, 2013-02-11 22:45:48
Looks like big Pharma hasn't made enough money yet so they are pushing this back as far as possible, with millions of terminally ill aids patients, there is Zero excuse for the delay.
cheryl whitten, Columbus Ga., 2013-02-09 21:21:47
Im not Ashamed!!! No livin in tha shadows its not my fault, I was diagnosed set 17 /1994 ,, im still here .. It is what is .. Im thankful to see soo many comin forward.. Its inspiring..
JY, s.c., 2013-02-07 17:52:01
What I don't understand is that if you have a potential cure then why don't they put all means possible into getting it out to the masses, it just doesn't make any sense to keep prolonging and prolonging, all it makes you think is that the FDA and the govnernment, also the pharmacutical companies are all in cohoots pushing cures back, there talking about one of the worst disease in man kinds history and they don't want to cure it, it's all about money I believe they have the cure there just hold
pritta, delhi, 2013-01-30 13:05:55
this is good but the said gene therapy should be tested on human body to determine its effectiveness. We all are hoping for the best outcome.
LES, San Francisco, 2013-01-30 12:40:16
Where are the ACT UP member who whold chain themselves to the door of FDA and demand this and other potential cures be expedited!
Marcus Carter, Savoy, 2013-01-29 16:56:42
Why do all these reports always include "in five years"?
Tiger Milner, South Florida, 2013-01-29 14:20:31
This is amazing news. But human trials will not begin for another five years? FIVE YEARS! Why? Why not immediately? This is vital, urgent, and important new information. Not something to put on the back burner.
Gail Kruger, Brakpan South Africa, 2013-01-29 12:08:08
I,m very excited about this treatment an offer myself as a human trail.
Tom, , 2013-01-26 18:31:34
"another five years" seems to been Science's answer to the deadbeat's claim that "the check is in the mail".
jimmok, dc, 2013-01-26 08:34:55
comments 1 - 15 (of 15 total)
Its always gr8 to hear something new in the fight against HIV but i have been reading all sort of successes for the last fifteen years with nothing materializing and i still think nothing is gonna be there till the next 20 years.m so frustrated and sad.any news about SANGAMOS ZFN or BIONOR"S VAc-4X or any thing thats in the final stages of trials.
[Go to top]