March #186 : Treatment: Atripla vs. Stribild and Complera - by Benjamin Ryan

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Features

Achieving the End

Falling Through the Cracks

From the Editor

Let's Stay Together

Feedback

Letters-March 2013

The POZ Q+A

Opening New Doors

POZ Planet

Turn Up the Music

Bookmarks

Country Remedy

Promoting PrEP

Native Talents

Bare Facts

All Dolled Up

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The 360 Approach

Care and Treatment

See You in Six Months?

Studying Risk Factors for Mental Decline

Implementing Health Care Reform

Pregnant Women Struggling With Adherence

GMHC Treatment Issues March 2013

HPV Vaccine May Benefit Women With HIV

Research Notes

Prevention: Latino Epidemic Varies by Region

Treatment: Atripla vs. Stribild and Complera

Cure: A Cat-and-Mouse Vaccine Game

Concerns: Ex-Inmates Aren’t Retained in Care

POZ Survey Says

Listen to Your Heart

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Farewell, Friend

   
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The HIV Life Cycle

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Hepatitis & HIV


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March 2013

Treatment: Atripla vs. Stribild and Complera

by Benjamin Ryan

Atripla (efavirenz/emtricita-bine/tenofovir) still reigns supreme, but two other drugs might work as well, or even better, when used as components of single-tablet, once-a-day combination regimens for treatment-naive people with HIV. Two Phase III, placebo-controlled clinical trials showed that Stribild (elvitegravir/cobicistat/tenofovir/emtricitabine) was as effective as Atripla as well as boosted Reyataz (atazanavir plus ritonavir) plus Truvada (tenofovir), helping it gain FDA approval in August 2012. Meanwhile, Complera (emtricitabine/rilpivirine/tenofovir), which was approved in 2011, proved to be as potent as, and in some cases more so than, Atripla in an open-label Phase IIIb study. Among a group who started the trial with viral loads below 100,000, an undetectable viral load was achieved by 88 percent of those taking Complera and 81 percent of those on Atripla. This was a statistically significant difference, but the results are clouded by concerns that those who fail Complera may have a higher risk of drug resistance.

Search: Atripla, Stribild, Complera, healthcare, AIDS, HIV,

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