Treatment News : Heart Attack Risk Rises if CD4s Ever Dip Below 200

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November 11, 2013

Heart Attack Risk Rises if CD4s Ever Dip Below 200

The risk of heart attack among people with HIV is linked to a depleted immune system, specifically if CD4s dip below 200, aidsmap reports. Similarly, keeping CD4s at or above 500 means no greater risk for heart attack when compared with HIV-negative controls. Publishing their findings in the Journal of Acquired Immune Deficiency Syndromes, investigators conducted a case-controlled study of 22,081 people with HIV who were matched with 230,069 HIV-negative controls, all of whom received care through the Kaiser Permanente California health plan between 1996 and 2009.

With a mean 4.5 years of follow-up and 99,090 person years provided for analysis, the HIV-positive group experienced 283 heart attacks, for an incidence of 283 per 100,000 person–years. With a mean 5.4 years of follow-up and 1,253,550 person-years provided for analysis, the HIV-negative group experienced 2,064 heart attacks, for an incidence of 165 per 100,000 person-years.

After controlling for various factors, the researchers found that HIV on the whole was linked to a 44 percent increase in the likelihood of heart attack compared with HIV-negative controls. Those people with HIV who were taking antiretrovirals had a 50 percent increased risk of heart attack when compared with the controls.

Those HIV-positive people with either a current CD4 level below 200 or whose lowest-ever CD4 count dropped below this number had a respective 76 and 74 percent greater likelihood of heart attack when compared with the HIV-negative group. Those who never experienced a CD4 count at or below 500 had no greater risk of heart attack than the control group.

To read the study, click here.

To read the aidsmap story, click here.

Search: Heart attack, CD4s, aidsmap, 500, 200, Journal of Acquired Immune Deficiency Syndromes, Kaiser Permanente California.


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