Having higher levels of “bad” low-density lipoprotein (LDL) cholesterol is associated with a better response to hepatitis C (HCV) treatment in people infected with both HIV and HCV, say the authors of a study published in the May 11 issue of AIDS. This raises the question of whether a problematic side effect of many antiretroviral (ARV) drugs—increases in LDL—may actually be advantageous for people living with HIV undergoing treatment for HCV.
In people infected with HCV, but not HIV, studies have found that having a higher total cholesterol level and higher levels of LDL cholesterol is associated with having a sustained virologic response (SVR) to HCV treatment. An SVR is defined as an undetectable HCV viral load six months after completing HCV treatment. José del Valle, MD, from the Hospital Universitario de Valme in Sevilla, Spain, and his colleagues set out to determine whether the same thing would be true in people coinfected with HIV and HCV. From a cohort of 3,564 coinfected patients, del Valle’s team analyzed data from 339 who had received HCV treatment.
In all, 39 percent of the patients who were treated achieved an SVR. People with a higher LDL cholesterol level (above 100 mg/dL) were more likely to have an SVR. This result was statistically significant, meaning that the difference was too great to have occurred by chance. Total cholesterol, however, did not influence whether people had an SVR. Given the beneficial impact of higher LDL on HCV treatment, del Valle’s team concludes that further analysis of the use of various ARV drugs most likely to elevate LDL levels should be conducted.
NEW! Scroll down to comment on this story.
Please click OK to confirm your comment and confirm you accept our posting rules. Note your message will be reviewed by our staff before going live.
Previous Comments:
comments 1 - 1 (of 1 total)
Samuel, Washington DC, 2008-05-14 10:42:40
Well for someone that is going to undergo treatment for Hep C soon it is a slight ray of sun considering the treatment is not fun. I just learned that my cholestrol has gone up after being so good for years. We need all the help that we can get.
People in neighborhoods all over New
York City recognize C. Virginia Fields. For nearly 20 years she played
several major roles in city government—including a seven-year term as
Manhattan Borough President and a run for mayor. Now, as the new
president and CEO of the National Black Leadership Commission on AIDS
(NBLCA), she brings her political energy to a different campaign:
Battling HIV/AIDS in the African-American community.
Woman of the Month is supported by exclusive advertising from Gilead.
Overheard in the Women's Forum
"My first son was born naturally—a month early—and was 8 lbs 7 ounces. I had to work that day and offloaded an 18 wheeler with an electric pallet jack so maybe all that vibration got me started. All four of my kids took AZT and didn't really mind it at all. I would recommend having a nipple put aside just for this because sticking the suction thingy in their mouths did not work so well, for me anyway."
