Treatment News : 12 Weeks of GS-7977 Plus Ribavirin Not Effective for Null Responders With Hep C Genotype 1 - by Tim Horn

POZ - Health, Life and HIV
Subscribe to:
POZ magazine
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join

Back to home » Treatment News » March 2012

Most Popular Links
Most Popular Lessons

The HIV Life Cycle


Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

20 Years Ago In POZ

More Treatment News

Click here for more news

Have news about HIV? Send press releases, news tips and other announcements to


March 7, 2012

12 Weeks of GS-7977 Plus Ribavirin Not Effective for Null Responders With Hep C Genotype 1

by Tim Horn

CROI 2012Despite rapid reductions in hepatitis C virus (HCV) levels in 10 previously treated null responders with genotype 1 HCV, only one person had a sustained virologic response (SVR), or viral cure, after treatment with a 12-week, pegylated interferon-free treatment regimen containing GS-7977 and ribavirin.

These results from the ELECTRON study, an ongoing Phase II clinical trial, were presented by Edward Gane, MD, of the Auckland City Hospital in Auckland, New Zealand, on Tuesday, March 6, at the 19th annual Conference on Retroviruses and Opportunistic Infections in Seattle.

Gane also reviewed preliminary data involving a group of people living with genotype 1 HCV starting treatment for the first time with GS-7977 plus ribavirin in the ELECTRON study. All study volunteers in this group had undetectable viral loads by the fourth week of treatment and have maintained these undetectable levels throughout therapy. Final results from this particular ELECTRON group are expected to be reported next month at the annual European Association for the Study of the Liver conference in Barcelona.

GS-7977—previously known as PSI-7977—is a once-daily nucleotide analog originally developed by Pharmasset, a company that was recently acquired by Gilead Sciences.

Strong results from another ELECTRON study group, involving people with genotype 2 or 3 HCV treated with 12 weeks of GS-7977 plus ribavirin, have been reported.

The ELECTRON data reviewed in full by Gane at CROI involved genotype 1 null responders—individuals who do not see their HCV viral load decrease by at least 2 log (at least 99 percent) after three months of therapy with pegylated interferon and ribavirin. Successful retreatment of null responders, even with a regimen containing a newly approved hepatitis C protease inhibitor, has been historically difficult.

The 10 null responders included in ELECTRON saw their HCV viral loads drop rapidly with a regimen of GS-7977 and ribavirin. All viral loads became undetectable by week four, which is termed a rapid virologic response (RVR) and is typically a strong predictor of curative treatment. These viral loads remained fully suppressed during therapy. However, all but one study volunteer experienced rapid rebounds in their HCV viral loads after finishing their 12-week treatment course.

The lone cure occurred in a young white woman who had minimal liver scarring and the IL-28B CC genotype, which is linked to a greater likelihood of being cured with interferon-based treatment.

Nobody discontinued treatment prematurely, and the adverse events were mild to moderate. One study participant experienced anxiety and depression, another developed anemia, and another—who was also taking the blood thinner warfarin—experienced a drop in platelets.

“Future studies of GS-7977 in the genotype 1 prior null responder population will likely require a longer duration of treatment, or the addition of another [direct acting antiviral,” Gane said.

Search: GS-7977, PSI-7977, Gilead, nucleotide analog, hepatitis C, coinfection, genotype 1, null responders, Gane, Seattle, CROI

Scroll down to comment on this story.


(will display; 2-50 characters)


(will NOT display)


(will display; optional)

Comment (500 characters left):

(Note: The POZ team reviews all comments before they are posted. Please do not include either ":" or "@" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules

Show comments (0 total)

[Go to top]

Facebook Twitter Google+ MySpace YouTube Tumblr Flickr Instagram
Quick Links
Current Issue

HIV Testing
Safer Sex
Find a Date
Newly Diagnosed
HIV 101
Disclosing Your Status
Starting Treatment
Help Paying for Meds
Search for the Cure
POZ Stories
POZ Opinion
POZ Exclusives
Read the Blogs
Visit the Forums
Job Listings
Events Calendar
POZ on Twitter

Ask POZ Pharmacist

Talk to Us
Did you participate in an event for National Black HIV/AIDS Awareness Day 2016?


more surveys
Contact Us
We welcome your comments!
[ about Smart + Strong | about POZ | POZ advisory board | partner links | advertising policy | advertise/contact us | site map]
© 2016 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.