March #162 : Go With the Flow - by Suzanne Bopp

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Table of Contents
 

Leading Ladies

Wonder Women




Crystal Clear

Go With the Flow

A Tell-Tale Heart

Going Rogue

Medicine Chest

Shifting the Starting Lines

The Power of Pampering




POZ Q&A: Senator Kirsten Gillibrand

Big Talk in the Big Apple

Faith in Numbers

Tropic Thunder

Are You Positive You’re Negative?




Editor's Letter-March 2010

Your Feedback-March 2010

In Memoriam

GMHC Treatment Issues-March 2010



 
Most Popular Lessons

The HIV Life Cycle

Shingles

Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV


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March 2010


Go With the Flow

by Suzanne Bopp

We need more info about how HIV affects menstruation and menopause—and positive women can help provide it.

As she entered menopause nine years ago, Denise Drayton had questions. Would her HIV-positive status influence the way her body responded to hormonal changes? Could she treat the symptoms of menopause the same way an HIV-negative woman could? How might HIV affect her postmenopausal life and body?

“I wanted to find out about HIV and menopause, but there was nothing out there,” Drayton says. Even her doctor couldn’t provide much information.

Knowledge about how HIV affects menstruation has changed over time—not unlike life with HIV itself. The Women’s Interagency HIV Study (WIHS), one of the oldest (since 1993) and largest efforts to examine HIV and women, is an example. Initially, menstrual irregularities were a chief complaint of participants, suggesting some interaction between female hormones and the virus. “But [further research showed] it wasn’t so much HIV as other cofactors causing the problems,” says Susan Cu-Uvin, MD, professor of ob/gyn and medicine at Brown University in Providence, Rhode Island. “If you [eliminated] IV-drug use, alcohol and psychotropic drug [use, you saw that] it wasn’t really the HIV.”

Those findings matched results of other older studies, done when few treatment options were available and many participants had AIDS. As HIV meds became widely available, women’s menstrual irregularities seemed to disappear.

“[Today] we have a better grasp of factors associated with abnormal menstrual cycles: substance abuse, AIDS, wasting disease—it relates more to overall nutritional status,” says Kristine Patterson, MD, clinical assistant professor at the University of North Carolina School of Medicine in Chapel Hill. “If the body doesn’t have enough fat, production of estrogen and progesterone shuts down,” Patterson says. This can happen anytime a woman loses too much weight, and it is exacerbated by advanced HIV disease, which causes the body to burn calories more rapidly.

L. Jeannine Bookhardt-Murray, MD, medical director for Harlem United Community AIDS Center in New York City, still sees lots of menstrual irregularities among her patients. “The majority of the women have other issues, though,” she says. “They’re underweight, they may be using drugs.” Bookhardt-Murray tries to identify the cause of the menstrual problems and treats them the same ways she would for a woman who doesn’t have HIV. She checks for fibroids if heavy bleeding is the problem, say, and may prescribe oral contraceptives to even out menstrual cycles.

But Bookhardt-Murray is now seeing signs that HIV may indeed influence hormonal changes. “I do see that women with HIV tend to go into menopause earlier than others,” Bookhardt-Murray says, and that mirrors the results of a few small studies. Other questions follow. “When you’re postmenopausal, you’re at increased risk for cardiac disease, diabetes, etc., even without HIV,” Cu-Uvin says, adding: “Are positive women [who are] aging going to have more osteoporosis and diabetes?”

Bookhardt-Murray treats these problems as she would in negative women—and for now, seeing a doctor who works to identify and treat symptoms may be as valuable as knowing precisely how HIV affects these symptoms.

Researchers do know, however, that female hormones affect the virus—and that sex hormones generally have an impact on immunity. “We know that where a premenopausal woman is in her menstrual cycle affects her infectiousness,” Patterson says. “Estrogen plays a role—not only in HIV and the interplay of HIV and meds, but also in [the likelihood of] women transmitting and acquiring HIV.” Estrogen’s role may explain why women progress to AIDS at lower viral loads than men. “It’s not uncommon to see a woman with a viral load [as low as] 10,000 and a CD4 count of 200—with AIDS. That’s less commonly seen in men,” Patterson says. “And women lose CD4 cells at different rates.” Estrogen’s specific role in CD4 loss is still under study.

Patterson also points out that for negative women, aging increases the risk of contracting HIV. “Postmenopausal women are probably at a greater risk of acquiring HIV with a smaller number of sexual encounters, or [with] a partner who has controlled HIV, because of physiological changes in the vaginal tract,” she says. “There are fewer natural secretions; there may be small abrasions.” Those changes might also make positive women more vulnerable to other sexually transmitted infections.

That’s why Bookhardt-Murray makes every effort to make sure all her patients are using condoms—at every age. “We have to get older people to realize [condoms] aren’t just for pregnancy prevention,” she says. “It’s a different education on condoms after their periods are over.”

These issues will become more pressing in coming years—and more possible to study. “This is the first generation of aging HIV-positive women,” Cu-Uvin says. “There’s no other cohort you can look at.” A few years ago, she designed a study on the interactions of ARVs and hormone replacement therapy, but she had trouble getting participants.

Denise Drayton would have appreciated knowing the results of such a study as she started menopause. As it turned out, she had little difficulty: some irritability and a few mild hot flashes.

For answers, we need the government to fund long-term studies—starting now. “Individual independent researchers can look at snapshots, but it will cost millions to follow women over time,” Cu-Uvin says. And convincing women to participate in those studies is still a challenge. “Gay men have [historically] wanted to be part of HIV advances. Women are less advocates of their own disease,” Cu-Uvin says. “But we need women to join those studies. There won’t be answers if you don’t volunteer.”

Self-Care Tips
For HIV-positive women with—or without—hormonal irregularities
  • Stay on top of your health—don’t put off regular visits to the ob/gyn.
  • If you’re nervous, take a trusted friend to the doctor’s office with you.
  • Be prepared to bring up your hormone-related symptoms if your provider doesn’t ask—and talk freely, providing details.
  • Ask specifically about getting hormone levels checked if you are experiencing irregularities.
  • If you don’t feel that your provider is communicating well, consult a patient advocate.
  • Take care of yourself: Exercise regularly, eat well and get at least seven hours of sleep nightly. Exercise has been shown to help ease some symptoms of menopause.
  • Consider enrolling in studies of women and HIV to help find answers—and improve the lives of all positive women.

Search: menopause, menstruation, hormones, postmenopausal, Woman's Interagency HIV Study, WIHS, edtrogen, period, hormone replacement therapy


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  comments 1 - 4 (of 4 total)    

L Priddy, Crawford, 2010-03-08 18:30:23
I am now 45 and working on living w/HIV for 20+. Wanting to be elegant, graceful, and dignified, I instead, find myself soaked, moody, irritable, I haven't had my cycle for almost 3yr. The moon used to help diagnosis why I was so tired, vomited, moody, and my womaness. Goodbye moon, hello ocean. WE NEED RESEARCH! I will go anywhere for help, with menopause. Never know I would be gifted with these discomforts.

Rosetta, Buffalo, NY, 2010-03-05 10:36:16
Being positive for almost 1/2 of my life, (52 on 3/22) and never experiencing menopause before...I have nothing to compare it to, I was glad the night sweats were menopause and not HIV related...I guess if I can survive HIV, menopause for me is just another challenge among many life seems to come with! Keep your heads up and your fans nearby my sistas!!!

Kat, Queens, New York, 2010-03-03 13:33:20
Even though my Doctor is wonderful I still think that they still do not know what effects HIV has on us women. I would love to start a group for women over 45 to discuss these issues and see if we can't all put our heads together to get the clinical world to take us seriously.

Islandgirl, Las Vegas, 2010-02-23 16:53:22
I have been poz for over 20yrs. Suffered the stigma that goes with it and survived 3 attacks of cervical cancer and eventually the uterus. At 45, without my women parts but still suffering through menopause. Loads of fun.... My docs had no plan and no idea what to do. Most just assumed I was a drug addict, which I am not, and most prescribed me meds that had horrible side effects that almost killed me. Double fun! Still have my humor, but still no doc who cares or wants to deal w/our needs

comments 1 - 4 (of 4 total)    

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