Treatment News : New Reyataz Dosing Recommendations for HIV-Positive Pregnant Women

POZ - Health, Life and HIV
Subscribe to:
POZ magazine
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join

Back to home » Treatment News » February 2011

Most Popular Links
Most Popular Lessons

The HIV Life Cycle


Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

20 Years Ago In POZ

More Treatment News

Click here for more news

Have news about HIV? Send press releases, news tips and other announcements to


February 7, 2011

New Reyataz Dosing Recommendations for HIV-Positive Pregnant Women

Bristol-Myers Squibb (BMS) has issued new dosing recommendations for HIV-positive pregnant women who wish to use Reyataz (atazanavir) as part of an antiretroviral (ARV) regimen. The new dosing recommendation is particularly important for treatment-experienced women using tenofovir (found in Viread and Truvada) or an acid-reducing H2 receptor antagonist.

Determining the proper dose of antiretroviral (ARV) drugs during and immediately following pregnancy is not always simple. During the last three months of pregnancy—referred to as the third trimester—the volume of blood in the woman’s body increases significantly, as do certain hormones that can affect how quickly drugs get broken down. This means that the concentrations of certain drugs in the blood during this time period can become too low to remain effective.

The risk of lowered efficacy, combined with the challenges and risks of studying drugs in pregnant women, means that dosing recommendations for pregnant women are often delayed years after a drug is approved for adults in the general population.

Now BMS has announced the results of a study that charted how blood levels of Reyataz change during and immediately following pregnancy. In general, blood levels of Reyataz went down during the third trimester of pregnancy and were increased in the couple of months immediately following the birth of the baby—known as postpartum.

Based on analyses of these data, BMS—in conjunction with the U.S. Food and Drug Administration—is recommending different Reyataz dosing schedules during the third trimester, which depend on a pregnant woman’s treatment history along with the other medications she is using. The company also recommends that all pregnant women be watched carefully for increases in side effects during the postpartum period.

BMS reiterates that Reyataz should always be used in combination with Norvir during pregnancy. Though unboosted Reyataz—Reyataz not used in conjunction with low-dose Norvir—is an approved treatment option, it is not recommended for pregnant women.

Generally speaking, pregnant women can use the standard Norvir-boosted Reyataz dose: 300 milligrams (mg) Reyataz combined with 100 mg Norvir.

Women in the second or third trimester of pregnancy who are treatment experienced—meaning they have been on other HIV drug regimens in the past—and are taking the drug tenofovir or an H2 receptor antagonist should take 400 mg Reyataz combined with 100 mg Norvir. Examples of H2 receptor antagonists include Tagamet (cimetidine), Pepcid (famotidine) and Zantac (ranitidine).

According to BMS, there aren’t enough data to recommend a proper dose of Reyataz for treatment-experienced pregnant women using both tenofovir and an H2 receptor antagonist at the same time.

Search: Pregnant, pregnancy, Reyataz, atazanavir, Norvir, ritonavir, tenofovir, Viread, Truvada, Atripla, third trimester, post-partum, blood levels, Bristol-Myers Squibb

Scroll down to comment on this story.


(will display; 2-50 characters)


(will NOT display)


(will display; optional)

Comment (500 characters left):

(Note: The POZ team reviews all comments before they are posted. Please do not include either ":" or "@" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules

Show comments (0 total)

[Go to top]

Facebook Twitter Google+ MySpace YouTube Tumblr Flickr Instagram
Quick Links
Current Issue

HIV Testing
Safer Sex
Find a Date
Newly Diagnosed
HIV 101
Disclosing Your Status
Starting Treatment
Help Paying for Meds
Search for the Cure
POZ Stories
POZ Opinion
POZ Exclusives
Read the Blogs
Visit the Forums
Job Listings
Events Calendar
POZ on Twitter

Ask POZ Pharmacist

Talk to Us
Did you participate in an event for National Black HIV/AIDS Awareness Day 2016?


more surveys
Contact Us
We welcome your comments!
[ about Smart + Strong | about POZ | POZ advisory board | partner links | advertising policy | advertise/contact us | site map]
© 2016 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.