September 4, 2008

HIV Vulnerability Linked to Spread of Roman Empire

People living in countries once ruled by the Roman Empire may be more susceptible to HIV infection, NewScientist.com reports.

According to the article, those hailing from countries such as England, Greece, France and Spain are less likely to carry a gene variant—called CCR5-Delta32—that produces a protein receptor HIV cannot bind to. Those who carry this variation have shown to have some resistance to infection, with slower progression to full-blown AIDS than those without it.

Researchers are unsure as to how this genetic difference originated, but some speculate that occupying Romans may have introduced a contagion that people with the variant were particularly susceptible to. Gene prevalence suggests that as the Romans moved their empire north, the disease may have wiped out people with the variant. More than 15 percent of people in certain areas of northern Europe carry the genetic variation compared with 4 percent of Greeks

Search: Roman Empire, CCR5-Delta32, England, Greece, France , Spain

Scroll down to comment on this story.

Previous Comments:

Ham Brower, NYC, 2010-05-20 20:44:56
Everyone, do a search on google for HIV Entry Inhibitors and find a wealth of information about CCR5 and CXCR4 which are both CD4 Receptors that the HIV virus binds to in order to enter the cell in the first place. Also, there are inhibitors which are being tested that block the protein "binder" on the virus itself to block its' ability to bind to the CD4 cell as well. Interesting stuff. I am very interested in these entry inhibitors AND Delta32 mutation as stem cell treatment options.

Luis Lopez-Detres, New York, 2008-09-09 10:04:22
This article is wrongly written when it says "CCR5-Delta32—that produces a protein receptor HIV cannot bind to." In fact is the Delta 32 deletion the reason why CCR5 is not produced and therefore, HIV can not bind to.