Treatment News : T Memory Stem Cells Are Likely a Cornerstone of HIV Reservoir

POZ - Health, Life and HIV
Subscribe to:
POZ magazine
Newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:

Back to home » Treatment News » January 2014

Most Popular Lessons

The HIV Life Cycle

Shingles

Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

15 Years Ago In POZ


More Treatment News

Click here for more news

Have news about HIV? Send press releases, news tips and other announcements to news@poz.com.


emailprint

January 13, 2014

T Memory Stem Cells Are Likely a Cornerstone of HIV Reservoir

Long-living, HIV-infected immune cells that have stem-cell-like properties appear to be a bedrock of the viral reservoir that prevents antiretroviral treatment from clearing the virus. Publishing their findings in Nature Medicine, researchers tested samples of blood drawn from people shortly after they acquired HIV, as well as samples from several years down the line, and then compared the viral sequences found in what are called T memory stem cells.

The scientists found that the viral sequences in the memory cells circulating shortly after infection were similar to those found in the memory cells following six to 10 years of ARVs. This suggests that the virus persisted in these cells without significant changes over an extensive period of time. Also, the amount of HIV’s DNA found in the memory cells remained essentially the same across the years, regardless of the fact that HIV treatment had depleted the level of virus in other types of immune cells. In fact, in those receiving treatment, the amount of HIV DNA was highest in their T memory stem cells. The conclusion is that T memory stem cells can continuously produce new HIV-infected immune cells while evading ARV treatment.

“Our findings suggest that novel, specific interventions will have to be designed to target HIV-infected T memory stem cells,” Mathias Lichterfeld, MD, an assistant professor of Medicine at Harvard Medical School and a corresponding author of the report, said in a release. “Methods of inhibiting stem cell pathways are being studied to eliminate cancer stem cells—persistent cells that are responsible for tumor recurrence after conventional treatments kill proliferating tumor cells. We are now investigating whether any of the drugs that target cancer stem cells might be effective against HIV-infected T memory stem cells.

“Identifying the reservoirs for HIV persistence is a critical step toward developing interventions that could induce a long-term remission without the need for antiviral medication, or possibly eliminate the virus entirely,” Lichterfeld continued. “Although a real cure for HIV has been elusive, it is not impossible.”

To read a copy of the release, click here.

To read the study abstract, click here.

Search: T memory stem cells, HIV, reservoir, Nature Medicine, Mathias Lichterfeld, Harvard Medical School.


Scroll down to comment on this story.



Name:

(will display; 2-50 characters)

Email:

(will NOT display)

City:

(will display; optional)

Comment (500 characters left):

(Note: The POZ team reviews all comments before they are posted. Please do not include either ":" or "@" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules



Show comments (1 total)

 
[Go to top]


Facebook Twitter Google+ MySpace YouTube Tumblr Flickr Instagram
Quick Links
Current Issue

HIV Testing
Safer Sex
Find a Date
Newly Diagnosed
HIV 101
Disclosing Your Status
Starting Treatment
Help Paying for Meds
Search for the Cure
POZ Stories
POZ Opinion
POZ Exclusives
Read the Blogs
Visit the Forums
Job Listings
Events Calendar
POZ on Twitter

Ask POZ Pharmacist

Talk to Us
Poll
Have you ever been diagnosed with diabetes or pre-diabetes?
Yes
No

Survey
Pop Watch

more surveys
Contact Us
We welcome your comments!
[ about Smart + Strong | about POZ | POZ advisory board | partner links | advertising policy | advertise/contact us | site map]
© 2014 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.