Treatment News : Steroid Injections Mixed With PIs Threaten Cortisol Levels

POZ - Health, Life and HIV
Subscribe to:
POZ magazine
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join

Back to home » Treatment News » July 2013

Most Popular Links
Most Popular Lessons

The HIV Life Cycle


Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

20 Years Ago In POZ

More Treatment News

Click here for more news

Have news about HIV? Send press releases, news tips and other announcements to


July 1, 2013

Steroid Injections Mixed With PIs Threaten Cortisol Levels

Those taking antiretroviral (ARV) regimens based on protease inhibitors (PIs) and who also receive corticosteroid injections are at risk of developing dysfunctional cortisol (stress hormone) levels, aidsmap reports. Reporting their findings in the Journal of Acquired Immune Deficiency Syndromes, researchers conducted a retrospective study of the records of 170 HIV-positive people who received corticosteroid injections in Boston’s Partners HealthCare system between 2002 and 2011.  

Eighty-one of the study participants (47 percent) were on a PI-based drug regimen; 56 (33 percent) were on non-PI-based ARVs; and 29 (17 percent) had not yet begun therapy.  

Among the group, nine (5 percent) developed a hypothalamic-pituitary-adrenal- (HPA) axis dysfunction. Five of this group also had evidence of Cushing’s syndrome, indicating exposure to elevated cortisol levels over a prolonged period. All nine of these study participants were taking PIs, resulting in an 11 percent prevalence of HPA-axis dysfunction in people taking this class of HIV therapy.

Possible symptoms of an HPA-axis dysfunction include excessive fatigue, changes in mood, increased appetite and weight gain, high blood pressure, weakness, bruising and fungal infections of the skin.

To read the study abstract, click here.

To read the aidsmap story, click here.

Search: HIV, antiretrovirals, cortisol, corticosteroid injections, Journal of Acquired Immune Deficiency Syndromes, Partners HealthCare, hypothalamic-pituitary-adrenal- axis dysfunction, HPA axis dysfunction, Cushing's syndrome.

Scroll down to comment on this story.


(will display; 2-50 characters)


(will NOT display)


(will display; optional)

Comment (500 characters left):

(Note: The POZ team reviews all comments before they are posted. Please do not include either ":" or "@" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules

Show comments (0 total)

[Go to top]

Facebook Twitter Google+ MySpace YouTube Tumblr Flickr Instagram
Quick Links
Current Issue

HIV Testing
Safer Sex
Find a Date
Newly Diagnosed
HIV 101
Disclosing Your Status
Starting Treatment
Help Paying for Meds
Search for the Cure
POZ Stories
POZ Opinion
POZ Exclusives
Read the Blogs
Visit the Forums
Job Listings
Events Calendar
POZ on Twitter

Ask POZ Pharmacist

Talk to Us
Did you participate in an event for National Black HIV/AIDS Awareness Day 2016?


more surveys
Contact Us
We welcome your comments!
[ about Smart + Strong | about POZ | POZ advisory board | partner links | advertising policy | advertise/contact us | site map]
© 2016 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.