Treatment News : Changing Meds May Be Unneeded After PI Treatment Failure

POZ - Health, Life and HIV
Subscribe to:
POZ magazine
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join

Back to home » Treatment News » June 2014

Most Popular Lessons

The HIV Life Cycle


Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

20 Years Ago In POZ

More Treatment News

Click here for more news

Have news about HIV? Send press releases, news tips and other announcements to


June 11, 2014

Changing Meds May Be Unneeded After PI Treatment Failure

Those who experience virologic failure when taking a first-line ritonavir-boosted protease inhibitor (PI) to treat HIV may be better off staying on that regimen, aidsmap reports. Publishing their findings in Clinical Infectious Diseases, researchers conducted a retrospective analysis of 209 participants in three different AIDS Clinical Trials Group studies, all of whom experienced virologic failure while taking a first-line ritonavir-boosted PI plus two reverse transcriptase inhibitors (NRTIs) and who participated in at least 24 weeks of follow-up after the virologic failure.

Just one of the participants’ virus developed a major PI-related mutation. Sixty-six percent of the participants continued on the same drug regimen following the virologic failure. The rate of viral suppression was essentially the same at 24 weeks between those who stayed on the same drug regimen and those who switched: a respective 64 percent and 72 percent, a difference that was not statistically significant, meaning it could have occurred by chance.

Those who continued on the same regimen boasted lower resistance to NRTIs and an average of 275 CD4s, compared with 213 cells among those who switched.

Among those who stayed the course on their regimens, factors that were linked to subsequent full virologic suppression included achieving a viral load below 400 before virologic failure, having a viral load below 10,000 at virologic failure and maintaining perfect drug adherence following virologic failure. For those who switched meds, there was a link between achieving a viral load below 400 before the virologic failure and having a fully suppressed viral load 24 weeks later.

The researchers concluded that for those who fail a first-line ritonavir-boosted PI regimen who have little or no drug resistance, staying on those same meds is a “reasonable approach.” They also noted that improving adherence is key to doing well on treatment following virologic failure.

To read the aidsmap story, click here.

To read the study abstract, click here.

Search: Protease inhibitor, treatment failure, virologic failure, aidsmap, ritonavir.

Scroll down to comment on this story.


(will display; 2-50 characters)


(will NOT display)


(will display; optional)

Comment (500 characters left):

(Note: The POZ team reviews all comments before they are posted. Please do not include either ":" or "@" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules

Show comments (0 total)

[Go to top]

Facebook Twitter Google+ MySpace YouTube Tumblr Flickr Instagram
Quick Links
Current Issue

HIV Testing
Safer Sex
Find a Date
Newly Diagnosed
HIV 101
Disclosing Your Status
Starting Treatment
Help Paying for Meds
Search for the Cure
POZ Stories
POZ Opinion
POZ Exclusives
Read the Blogs
Visit the Forums
Job Listings
Events Calendar
POZ on Twitter

Ask POZ Pharmacist

Talk to Us
Has a pet helped you deal with your HIV?


more surveys
Contact Us
We welcome your comments!
[ about Smart + Strong | about POZ | POZ advisory board | partner links | advertising policy | advertise/contact us | site map]
© 2016 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.