Treatment News : Two Studies Raise Hopes for Female-Empowered HIV Prevention

POZ - Health, Life and HIV
Subscribe to:
POZ magazine
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join

Back to home » Treatment News » March 2014

Most Popular Lessons

The HIV Life Cycle


Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

20 Years Ago In POZ

More Treatment News

Click here for more news

Have news about HIV? Send press releases, news tips and other announcements to


March 12, 2014

Two Studies Raise Hopes for Female-Empowered HIV Prevention

CROI 2014After many years of failures, recent studies have moved researchers closer to a form of HIV prevention that women can use discreetly. At the Conference on Retroviruses and Opportunistic Infections (CROI) in Boston, researchers presented the results from two early studies of such prevention techniques. One study was on the first vaginal ring to use not one but two antiretrovirals (ARVs) as an arsenal against the virus, and the other study looked at a vaginal film as a potential alternative to a microbicide gel.

Called MTN-013/IPM 026, the Phase I study on the combination ring examined the safety and tolerability of a monthly ring containing the ARVs dapivirine and Selzentry (maraviroc). A group of female study participants randomly received either the dapivirine-Selzentry ring, a ring containing just Selzentry, or a placebo ring without either of the drugs. Biopsied cervical tissue taken from the women who used the combination ring showed that the drugs protected the tissue against HIV infection when exposed to the virus. The findings support the current Phase III study of a dapivirine-only ring that is being conducted in Africa.

While the researchers detected high levels of dapivirine in the blood, vaginal fluids and cervical tissues of those using the combination ring, Selzentry was only detectable in the vaginal fluid and in some women’s cervical tissue. The investigators theorize that a higher dose of Selzentry may be needed for the drug to have an appreciable effect.

The FAME-02 Phase I study examined the safety, drug absorption and drug distribution of a dapivirine film, comparing these qualities with those of a gel containing the drug. Researchers assigned 60 women to use a dapivirine film or gel, or placebos of the respective delivery methods, for a week. The researchers drew blood and tissue samples within two hours following the final dose. Then they exposed the tissue samples to HIV.

The researchers found that the gel and film delivered dapivirine to the bloodstream comparably. The gel led to higher levels of the ARV in the vaginal tissue than the film, but each method protected against HIV transmission.

To read a press release on the studies, click here.

Search: HIV, vaginal ring, vaginal film, microbicide, CROI, Conference on Retroviruses and Opportunistic Infections, MTN-013/IPM 026, dapivirine, Selzentry, maraviroc, FAME-02.

Scroll down to comment on this story.


(will display; 2-50 characters)


(will NOT display)


(will display; optional)

Comment (500 characters left):

(Note: The POZ team reviews all comments before they are posted. Please do not include either ":" or "@" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules

Show comments (0 total)

[Go to top]

Facebook Twitter Google+ MySpace YouTube Tumblr Flickr Instagram
Quick Links
Current Issue

HIV Testing
Safer Sex
Find a Date
Newly Diagnosed
HIV 101
Disclosing Your Status
Starting Treatment
Help Paying for Meds
Search for the Cure
POZ Stories
POZ Opinion
POZ Exclusives
Read the Blogs
Visit the Forums
Job Listings
Events Calendar
POZ on Twitter

Ask POZ Pharmacist

Talk to Us
Did you participate in an event for National Black HIV/AIDS Awareness Day 2016?


more surveys
Contact Us
We welcome your comments!
[ about Smart + Strong | about POZ | POZ advisory board | partner links | advertising policy | advertise/contact us | site map]
© 2016 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.