If you have lived with HIV for a long time and have exhausted various med combos in the past, there are still options. Here are a few:

Combine three newer meds: Prezista (darunavir, boosted with Norvir) plus Intelence (etravirine) and Isentress (raltegravir), when combined with other drugs the virus may be sensitive to, suppressed HIV for some people whose HIV combos had stopped working. Most of the group still registered undetectable viral loads after two years.

Add an experimental drug: Dolutegravir (S/GSK-572) is an integrase inhibitor—a drug that prevents HIV from hijacking the genetic material in your body’s cells to reproduce. In a complete HIV regimen and taken twice a day, dolutegravir allowed some long-termers to knock HIV to undetectable levels.

Add Reyataz (atazanavir) or Invirase (saquinavir) to your combo: This helped some people who had previously taken the protease inhibitors Kaletra (lopinavir/ritonavir), Lexiva (fosamprenavir) or Agenerase (amprenavir).