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Here is the scoop. When HIV infects a cell it becomes a part of the Human DNA and there is no way the viral genome can be seperated. Also to find those latent reservoirs is also a challenge and the immune system does not know which cell is infected. Hence a shock and kill approach is good, but it will also shock other latent reservoirs carrying other harmful viruses and the shock and kill approach can also fail. A CD8 T cell based vaccine could work, a passive vaccine..Samuel kumar zambia
I read this article after reading the dna snipping article. It seems likeep articles like this are good at dashing hope. Maybe instead of writing negative articles, supposedly trying to elicit reality in hopeful people, the author would be better to elicit hope in people living with this disease. It's the least we can do. Afterall, haven't most people with this disease dealt with enough doses of reality in their lifetime.
CURE ???? What cure. There will Never be a Cure(even if found)released to stop HIV. We are to big of a CASH Cow for All the Drug Companies. I once tried to add up the cost of MY HIV/AIDS healthcare. Close to $80,000.00 a year. Multiply that by 500,000.00 know infected and treated patients. WOW Loosing that to find a cure...RIGHT!
You have not mentioned CRISPR against viral reservoirs, in vitro a very successful gene editing technique which targets latent proviral HIV. Looks promising!
Hopefully someone will prove this writer wrong.
HIV cure will never be around the corner. HIV is to infectious diseases doctors what hypertension is to cardiologists or diabetes to diabetes doctors. Infectios diseases market needed a chronic patient and hiv is perfect for that. Imagine no more CROI, no more IAS...no more Gilead, no more business. The best we can hope are expensive long acting treatments. It is that simple people.
It seems to me that people with AIDS have all been forgotten about. I have been living with AIDS for over 22 years and now when I read POZ it is all about Hep C and HIV,When they find the cure will we the people with AIDS just be left behind, with their Hump backsanddrawn in temples,Iwent through 7-8 PCPs,CNS Lymphoma, Neutroprenia and too many to name because I forgot after 22 years. I also had to sue my former employer,that was 19 years ago, They went out of business. I hope it was my lawsuit.
Richard
Readers would do well to ask themselves why this magazine frequently facilitates activist interventions in some areas of HIV, but tosses its hands helplessly in the air and proclaims that a cure is nowhere around the corner.
April 19, 2016