American death rates for those with HIV-related lymphoma haven't budged during the modern era of antiretrovirals (ARVs). Lymphoma is the most frequent cause of cancer-related deaths among people with HIV. Analyzing data from nearly 500 people who were diagnosed with various forms of HIV-related lymphoma between 1996 and 2010, researchers found that those diagnosed more recently did not have an improved chance at survival. The lymphoma types included in the study were non-Hodgkin's, Hodgkin's, diffuse large B-cell, Burkitt's and primary central nervous system lymphoma. Those who developed lymphoma while taking ARVs had a doubled mortality rate, which might indicate differences between the types of tumors that develop when someone is on therapy versus off; more research is needed on this topic.