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Disabling CCR5 Could Be Key to a Cure—but at What Cost?

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7 Comments

mcaplanov

Here is the article about the errors in the study: https://www.statnews.com/2019/09/27/major-error-undermines-study-suggesting-change-introduced-in-the-crispr-babies-experiment-shortens-lives/ (the change introduced being the CCR5-32 delta deletion)

September 3, 2020

mcaplanov

The study demonstrating reduced fitness has since been recalled due to poor technique. After some adjustments it no longer appears as though these individuals have statistically significant increased mortality

September 3, 2020

32yrsPOZ&StillHERE

At my age, after having lived with HIV for 32 years, a cure seems a low priority for me. The various drugs (who knows which ones?) kept me alive. My CD4’s have hovered between 600 and 800 for decades. My once-a-day antiviral today seems like a miracle compared to the old days when it three doses of meds, and an injection every day. But I understand how important it could be for anyone with several decades left to live. A cure in my 30s could have changed much in my life. I hope I see it happen!

June 26, 2019 Las Vegas, NV

KnowledgeISpower

Thank you for this information article. After 27 years since being diagnosed I'm amazed at the progress that has been made. I am confused about why people would be angry over this article. Maybe it's my age, or the fact that I spent the 90's enrolling in every research study I could at Vanderbilt. I read these articles with an open mind hoping to increase my overall knowledge of HIV. It boggles my mind why an individual would become angry over an article that is informative. #DontWorryBHappy

June 26, 2019 Nashville

CCR5monkey

I was infused with my own genetically modified stem cells having the CCR5 deleted 2 years ago. Many factors including the chemotherapy applied have delayed the grow of CD4 cells. Soon we will know if this approach will work.

June 25, 2019

Andrew

This magazine is a joke. If this were another drug that to benefit the hiv- or the pharmaceutical industry, you could safely bet money Poz would come out swinging for it. Hey Poz, most of us don’t want to live with HIV. That includes people who actually do have it. How about you work for a aids free future for all of us for once? IRL, most of us would be happy to take some risk to be done with this.

June 23, 2019 Cleveland, OH

Nick44

I get to decide. My body, my choice. A 21% increase doesn't mean much to me when the data could be skewed by other genetic and external factors. At any rate, I'm willing to take my chances to stop this chronic inflammation, premature aging, and nearly two times the risk of heart attack due to HIV. How dare he mention HIV stigma when there are too many issues to count with this virus excluding other people's judgments! No more toxic pills and Big Pharma profits at our expense!

June 20, 2019 OKC

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