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Barebacking CD4 Cells

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3 Comments

A

Thank you for the very interesting information. I teach nursing and teach the HIV content. One of the assignments is to send the students to sites such as your's for information related to living with HIV, the impact of the medications, etc. The new information that I find on this site has been very enlightening and helpful.

April 9, 2009

Matthew

Very interesting indeed, So it is no wonder that all current vaccines have to fail. But there are new ones in development, Anti-PS/PE that target the cells, not the virus. Maybe they will have more luck in the future. Lets hope for gene theraphy or stem cells, Antibodies or drugs won't stop this evil virus :)

April 1, 2009

michael

Hi Peter, Thanks for posting this, and for a great blog in general. I'm sure it was just a typo but Isentress (aka Raltegravir) is an integrase inhibitor, not an entry one! Okay, what to make of this finding; well as a pozzie, I'm encouraged whenever something new is learnt about HIV, and this could have a real impact later on. However that excitement is tempered by the fact that this pet virus of mine is even more devious than imagined, and will take some stopping. Current projects in development such as entry inhibition, either by genetic engineering (Zinc Finger Nucleases), monoclonal antibodies (Pro 140, Ibalizumab) or epitope detection from "souped" up T cells all require HIV to enter as a free agent. Cell to cell HIV transfer will elude all these new attempts. So it's a bit depressing really. Would be interested to know what others think. M.

April 1, 2009

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