Although we have witnessed a dramatic global scale-up of antiretroviral treatment (ART) as well as efforts to prevent vertical HIV transmission in the last decade, there were 160,000 new pediatric infections in 2018 and an estimated 1.7 million children <15 years of age living with HIV. Children are substantially less likely than adults to be diagnosed, initiate treatment, and achieve durable viral suppression. Currently, only 54% are receiving ART, and treatment of pediatric HIV infection, particularly in infants and young children, remains complex and problematic, with continued use of suboptimal ART formulations and regimens. Join this year’s edition to hear more on pediatric care and treatment, comorbidities, clinical cases, as well as the prevention of new pediatric HIV infections, and HIV in adolescents and young adults.