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More studies link dolutegravir and other drugs to weight gain among people with HIV.
The effect is greater for women, and it could have a detrimental effect on pregnancy outcomes at the population level.
Previously, kids weighing 44 to 88 pounds had to take lower doses—which are less available worldwide—and do so more than once a day.
A 2018 report had suggested that HIV-positive women’s use of the drug at conception increased the risk of the rare birth defects.
Two-drug antiretroviral regimens suppress viral load, but three-drug combos may offer additional benefits.
For pregnant women with HIV, dolutegravir-based regimens are apparently safest.
The agency has also lowered the weight threshold for film-coated tablets of the integrase inhibitor.
The study randomized women starting HIV treatment during their third trimester to dolutegravir- or efavirenz-based antiretroviral regimens.
Researchers compared the demographics of participants in randomized controlled trials for antiretrovirals with the global HIV population.
A recent small study examined pairings of antiretrovirals and statins or blood pressure medications.
Researchers compared regimens prescribed to pregnant women in their second trimester.
Findings suggest exposure to antiretrovirals, including dolutegravir, during pregnancy does not raise the risk of neural tube defects.
The latest revision recognizes the importance of treatment as prevention.
The integrase inhibitor–based HIV regimen was compared with dolutegravir-based regimens.
Researchers at George Washington University take a look.
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