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People who switched from tenofovir disoproxil fumarate to tenofovir alafenamide gained weight regardless of other meds.
The agency has also lowered the weight threshold for film-coated tablets of the integrase inhibitor.
A rundown of POZ’s reporting on the 2020 Conference on Retroviruses and Opportunistic Infections
Studies have found that weight gain is common after people with HIV begin an antiretroviral in this class.
Weight gain speeds up after switching to an integrase inhibitor from a non-nucleoside reverse transcriptase inhibitor.
Researchers at George Washington University take a look.
Future research should examine how particular combinations of antiretrovirals contribute to weight gain, according to one expert.
However, a recent study found that this varied based on the specific integrase inhibitor used.
This from a small study of people who switched from a boosted protease inhibitor to Isentress (raltegravir) or Tivicay (dolutegravir).
More high-quality evidence is needed to determine how this class of HIV medications may affect weight gain.
However, various disparities in such rates—based on race, age and HIV regimen—persist.
People who take integrase inhibitors are less likely to stop them due to health issues.
Tivicay (dolutegravir) is a next-generation integrase inhibitor.
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