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The technology, developed by Katalin Karikó and Drew Weissman, also holds promise for HIV vaccines and cancer treatment.
A boost in protection is needed to offset the persistent disparities in the toll of COVID between racial and ethnic groups.
People at lower risk may not need an updated booster, but without a CDC recommendation, insurance companies wouldn’t have to cover it.
People ages 6 months and older are eligible for new Moderna and Pfizer-BioNTech boosters targeting XBB.1.5 omicron variant.
Vaccine type, older age, male sex and especially smoking were associated with lower antibody responses.
People 65 and older and immunocompromised people can get a second bivalent booster; most unvaccinated people now need only one initial shot.
Older people, immunocompromised people and those with underlying health conditions can benefit most from additional shots.
Updated boosters could go to the “worried well” who have good insurance rather than to those at highest risk.
NIAID is preparing for the possibility of future variants evading protection against currently available COVID-19 vaccines.
HIV mutates rapidly, enabling the virus to evade the common, narrowly targeted antibodies produced by most people with HIV.
An NIH-sponsored study assessed boosters for adults fully vaccinated with any authorized or approved COVID-19 vaccine.
The experimental vaccine regimen aims to train B cells to produce broadly neutralizing antibodies against HIV.
New vaccine approach triggers neutralizing antibody production and T-cell responses and lowers risk of infection.
None of the available coronavirus vaccines have been linked to increased risk of HIV acquisition or disease progression.
Many people who received any of the authorized COVID-19 vaccines are now eligible for an additional dose of their choice.
People who received the Moderna COVID-19 vaccine had strong immune memory of SARS-CoV-2 six months after vaccination.
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