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People who saw substantial CD4 T-cell gains during the first two years after diagnosis had better outcomes.
Many participants on two-drug regimens had more treatment under their belt and more chronic conditions.
However, all integrase inhibitors were associated with similar weight gain.
Advocates claim Gilead and others unfairly limited competition for HIV combination pills.
Researchers at George Washington University take a look.
The newer tenofovir formulation can raise cholesterol and triglyceride levels, but these changes are reversible.
Swiss researchers analyzed shifts in kidney function among those switching from the old form of the HIV medication to the new one.
Tenofovir disoproxil fumarate is found in Truvada, Viread, Atripla, Complera and Stribild.
More high-quality evidence is needed to determine how this class of HIV medications may affect weight gain.
Gilead has based its entire HIV drug portfolio on updating tenofovir, ostensibly to make it safer for bones and kidneys.
This is according to a French study looking at discontinuations of Tivicay compared with Vitekta and Isentress.
Nevertheless, researchers advise careful kidney monitoring when pairing the medications.
That’s compared with HIV-negative men.
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