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The newer tenofovir formulation can raise cholesterol and triglyceride levels, but these changes are reversible.
Swiss researchers analyzed shifts in kidney function among those switching from the old form of the HIV medication to the new one.
Tenofovir disoproxil fumarate is found in Truvada, Viread, Atripla, Complera and Stribild.
More high-quality evidence is needed to determine how this class of HIV medications may affect weight gain.
Gilead has based its entire HIV drug portfolio on updating tenofovir, ostensibly to make it safer for bones and kidneys.
This is according to a French study looking at discontinuations of Tivicay compared with Vitekta and Isentress.
Nevertheless, researchers advise careful kidney monitoring when pairing the medications.
That’s compared with HIV-negative men.
Two men claim they developed bone and kidney problems after taking TDF. A related class action lawsuit has also been filed.
A new analysis finds that Gilead Sciences’ updated version of its key antiretroviral tenofovir may not actually offer any safety benefits.
Largest-ever analysis of bone loss in the HIV population found that treating hep C, taking vitamin D and exercising might be preventive.
Clinicians have presented a pair of case reports of patients going on the HIV medication and experiencing severe mental health reactions.
People with HIV taking Viread, especially if combined with Norvir, should receive regular kidney monitoring.
Increases may be designed to push patients to the company’s newer regimens.
Lawsuit: Gilead has manipulated the patent system to extend its control (and profit) of tenofovir, found in many HIV regimens.
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