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Gilead Sciences has released 96-week results from an ongoing double-blinded study comparing the two regimens.
So argued researchers behind a study that switched people from triple-antiretroviral regimens to Tivicay monotherapy.
This is according to a French study looking at discontinuations of Tivicay compared with Vitekta and Isentress.
A large ongoing study in Botswana has found that about 1 in 150 babies exposed to Tivicay at conception developed such birth defects.
Tivicay (dolutegravir) is a next-generation integrase inhibitor.
The integrase inhibitor is included in the single-tablet HIV regimens Triumeq and Juluca.
A recent meta-analysis compared side effects linked to Tivicay versus other antiretrovirals.
The newly approved single-tablet regimen contains the integrase inhibitor bictegravir plus emtricitabine and tenofovir alafenamide.
Highlights from HIV and hepatitis C research presented at the 2018 Conference on Retroviruses and Opportunistic Infections (CROI) in Boston
Ziagen is included in the combination-tablet regimens Triumeq and Trizivir and the two-drug combo tablet Epzicom.
Forty-eight-week results are in from a Phase III study that switched participants from Triumeq to Gilead’s new single-tablet regimen.
ViiV alleges that the bictegravir component of the tablet infringes on its own patent for Tivicay (dolutegravir).
The once-daily regimen includes the integrase inhibitor bictegravir plus the contents of Descovy (emtricitabine/tenofovir alafenamide).
More research is needed to determine the metabolic implications of this apparent association and how it may drive diabetes.
Clinicians have presented a pair of case reports of patients going on the HIV medication and experiencing severe mental health reactions.
Tivicay is included in Triumeq (dolutegravir/abacavir/lamivudine) and linked with insomnia in a small proportion of those on the HIV med.
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