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Hello Paul, on the research of kp 1461, is new? was interronpidas? will continue? thanks. sorry bad english. I am brazil.
Thanks for posting this, Paul. Ever since losing my childhood friend to HIV, I've done numerous research projects on the virus and have followed treatment breakthroughs daily. Hopefully this will be the beginning of the end for this pandemic.
Manfred, Even if this drug does pan-out, and viral accelerated decay is an effective approach to disarming HIV, it will still be difficult and probably impossible to reach the latently infected T cells and sanctuary sites such as lymph nodes and CNS tissue. Until a drug can do that, it will be premature to label it the "one". I wish I was wrong. Michael.
Hey Paul. Thanks for the new update on KP-1461. I thought it was shelved for good. I too followed the studies closely and was dissapointed when the studies were stopped due to ineffectivness after so much promise of this drug with a novel new mechanism of action. Please keep us informed of new developments. Hopefully this drug will be "the one". Unfortunately my great HIV doc tells me he has seen a number of such miracle drugs come and go over the years. Hope he is wrong. Manfred
Hi Paul, Thanks for posting. I agree with your caveat surrounding the ambiguous findings from studies done on KP-1461, but it looks like there might be some real promise this time. We'll have to wait and see. In any event, with the development of Beviramat, a novel maturation inhibitor, Pro-140 a humanised antibody Entry inhibitor and Depot formulation of Rilpivirine the new NNRTI, things are looking bright in the near future for those, like myself, with the virus, especially those who are treatment experienced, unlike myself. I'm interesting in becoming involved in the treatment field, as, well I'm not even sure. Any ideas? There are still issues regarding treatment in the UK, and for myself I would like to see a push towards infrequent dosing. Daily medication is still a constant reminder of being infected and is really annoying when you have to make your excuses and go to the toilet to take your meds....not forgetting with food!! Michael.
Henry
Michael, the idea is that this compound would, theoretically, eradicate HIV, even in the reservoirs, by creating a whole new, non-lethal, quasispecies. It's the only drug that eradicates HIV in vitro. The MOA is explained in this link: http://www.aidsnews.org/2007/10/kp-1461.html
October 19, 2009