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I have had some insurance issues, due to that there were a couple of periods when I did not have acyclovir, I discussed with my doctor about 2 years ago the fact that I get a bump to my t cells after restarting acyclovir. I only take Kaletra and acyclovir. T cells stay around 600, viral load about 75. HIV+ for 21 years.
Question, For those of us not co-infected with the Herpes Virus ,any of them, is there a way to attach the thymidine kinase enzyme to a normal, uninfected cell so that HIV could not go thru the phosphorylation step? Hence, not infecting a normal, healthy cell??? Can anyone get back to me on this? Thanks vnsatyr
Finnboy
vnsatyr, Yes. Valaciclovir (the phosphorylated prodrug version of acyclovir) - because of the way it processed by the body, bypasses the herpes requirement for HIV suppression to occur. The research mentions this. Valaciclovir is still patented though.
September 17, 2008